Analgesic Efficacy, Practicality and Safety of Inhaled Methoxyflurane Versus Standard Analgesic Treatment for Acute Trauma Pain in the Emergency Setting: A Randomised, Open-Label, Active-Controlled, Multicentre Trial in Italy (MEDITA)
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Therapy"
DOI: 10.1007/s12325-019-01055-9
Abstract: Inhaled low-dose methoxyflurane is approved in Europe for emergency relief of moderate-to-severe trauma-related pain in adults, but data versus active comparators are sparse. The phase IIIb Methoxyflurane in Emergency Department in ITAly (MEDITA) trial investigated… read more here.
Keywords: trauma pain; methoxyflurane; treatment; emergency ... See more keywords
Inhaled Methoxyflurane Provides Greater Analgesia and Faster Onset of Action Versus Standard Analgesia in Patients With Trauma Pain: InMEDIATE: A Randomized Controlled Trial in Emergency Departments.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of emergency medicine"
DOI: 10.1016/j.annemergmed.2019.07.028
Abstract: STUDY OBJECTIVE The objective of the InMEDIATE study was to evaluate the change in intensity of traumatic pain over the first 20 min in adult patients treated with methoxyflurane versus standard analgesic treatment in Spain.… read more here.
Keywords: methoxyflurane; treatment; analgesic treatment; emergency ... See more keywords
Efficacy and safety of methoxyflurane for treatment of acute traumatic pain by EMTs during alpine rescue operations: The "PainDrop" Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Prehospital emergency care"
DOI: 10.1080/10903127.2022.2107125
Abstract: Background: Treatment of acute traumatic pain is a core task for mountain rescue services. Intravenous access, however, is often difficult, and the vast majority of missions are carried out without a physician at the scene.… read more here.
Keywords: alpine; rescue; methoxyflurane; efficacy ... See more keywords
Efficacy and safety of inhaled low-dose methoxyflurane for acute paediatric pain: A systematic review
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DOI: 10.1177/1460408618798391
Abstract: Introduction Undertreatment of acute, moderate-to-severe pain in children is common, due in part to barriers to the use of opioids. Low-dose methoxyflurane is an inhaled, non-opioid analgesic widely used in Australia and recently approved in… read more here.
Keywords: acute; low dose; methoxyflurane; safety ... See more keywords
Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children—the MAGPIE trial (MEOF-002): study protocol for a randomised controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "Trials"
DOI: 10.1186/s13063-019-3511-4
Abstract: BackgroundPain from injuries is one of the commonest symptoms in children attending emergency departments (EDs), and this is often inadequately treated in both the pre-hospital and ED settings, in part due to challenges of continual… read more here.
Keywords: penthrox; randomised controlled; trial; methoxyflurane ... See more keywords
Serum fluoride levels in ambulance staff after commencement of methoxyflurane administration compared to meta-analysis results for the general public.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of occupational medicine and environmental health"
DOI: 10.13075/ijomeh.1896.01704
Abstract: OBJECTIVES Ambulance officers administering methoxyflurane as an inhalational analgesic may be exposed to trace vapor. Fluoride is a methoxyflurane metabolite, and has been associated with acute renal failure in anesthesia patients and skeletal fluorosis with… read more here.
Keywords: methoxyflurane; serum fluoride; skeletal fluorosis; serum ... See more keywords
Low-Dose Methoxyflurane versus Standard of Care Analgesics for Emergency Trauma Pain: A Systematic Review and Meta-Analysis of Pooled Data
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DOI: 10.2147/jpr.s292521
Abstract: Purpose Undertreatment of trauma-related pain is common in the pre-hospital and hospital settings owing to barriers to the use of traditional standard of care analgesics. Low-dose methoxyflurane is an inhaled non-opioid analgesic with a rapid… read more here.
Keywords: methoxyflurane; pain; standard care; care analgesics ... See more keywords
Clinical assessment and risk stratification for prehospital use of methoxyflurane versus standard analgesia in adult patients with trauma pain
Sign Up to like & getrecommendations! Published in 2023 at "Turkish Journal of Emergency Medicine"
DOI: 10.4103/tjem.tjem_229_22
Abstract: Oligoanalgesia, the undertreatment of trauma-related pain using standard analgesics in prehospital and emergency departments, has been extensively documented as one of the major challenges affecting the effective treatment of trauma-related pain. When administered in low… read more here.
Keywords: adult patients; methoxyflurane; dose methoxyflurane; pain ... See more keywords