Mannich base approach to 5‐methoxyisatin 3‐(4‐isopropylphenyl)hydrazone: A water‐soluble prodrug for a multitarget inhibition of cholinesterases, beta‐amyloid fibrillization and oligomer‐induced cytotoxicity
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DOI: 10.1016/j.ejps.2017.08.004
Abstract: &NA; Targeting protein aggregation for the therapy of neurodegenerative diseases remains elusive for medicinal chemists, despite a number of small molecules known to interfere in amyloidogenesis, particularly of amyloid beta (A&bgr;) protein. Starting from previous… read more here.
Keywords: mannich base; bgr; methoxyisatin isopropylphenyl; isopropylphenyl hydrazone ... See more keywords