Brain magnetic resonance imaging predictors in anti‐N‐methyl‐D‐aspartate receptor encephalitis
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DOI: 10.1002/acn3.51690
Abstract: Brain magnetic resonance imaging (MRI) findings in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are nonspecific and rarely have obvious associations with clinical characteristics and outcomes. This study aimed to comprehensively describe the MRI features of patients with… read more here.
Keywords: magnetic resonance; brain magnetic; resonance imaging; methyl aspartate ... See more keywords
Pregnancy, N‐Methyl‐D‐Aspartate Receptor Antibodies, and Neuropsychiatric Diseases
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DOI: 10.1002/ana.25654
Abstract: Pregnancy, N-Methyl-D-Aspartate Receptor Antibodies, andNeuropsychiatric Diseases Josep Dalmau, MD, PhD Jurek and colleagues used a recombinant monoclonal antibody (ab) derived from a patient with anti–N-methyl-D-aspartate receptor encephalitis (anti-NMDARe) to show that systemic administration to pregnant… read more here.
Keywords: receptor antibodies; pregnancy methyl; methyl aspartate; aspartate receptor ... See more keywords
N‐Methyl‐D‐Aspartate Receptor Antibodies in Autoimmune Encephalopathy Alter Oligodendrocyte Function
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DOI: 10.1002/ana.25699
Abstract: Antibodies against neuronal N‐methyl‐D‐aspartate receptors (NMDARs) in patients with anti‐NMDAR encephalitis alter neuronal synaptic function and plasticity, but the effects on other cells of the nervous system are unknown. read more here.
Keywords: methyl aspartate; aspartate; receptor antibodies; alter ... See more keywords
Phenol—Benzoxazolone bioisosteres: Synthesis and biological evaluation of tricyclic GluN2B‐selective N‐methyl‐ d‐aspartate receptor antagonists
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200147
Abstract: Tricyclic tetrahydrooxazolo[4,5‐h]‐[3]benzazepin‐9‐ols 22 were designed as phenol bioisosteres of tetrahydro‐3‐benzazepine‐1,7‐diols. Key features of the synthesis are the introduction of the trifluoromethylsulfonyl and allyl protective groups at the heterocyclic N‐atoms. Two methods were developed to convert… read more here.
Keywords: bioisosteres synthesis; glun2b; benzoxazolone bioisosteres; phenol benzoxazolone ... See more keywords
COVID‐19 and anti‐N‐methyl‐d‐aspartate receptor (anti‐NMDAR) encephalitis: Are we facing an increase in the prevalence of autoimmune encephalitis?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26745
Abstract: It has been a century since Constantin von Economo first reported patients who were initially hospitalized with unusual neurological symptoms with various diagnoses that did not show a complete feature of the disorder and while… read more here.
Keywords: methyl aspartate; anti methyl; covid anti; receptor anti ... See more keywords
Cervical Dystonic Tremor and Dysphonia—Rare Presentation of Anti–N‐Methyl‐D‐Aspartate Encephalitis and Its Management
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DOI: 10.1002/mdc3.13579
Abstract: The precise prevalence of anti – N -methyl- D -aspartate receptor encephalitis (anti-NMDARE) is unknown, and the disease is often underreported. This could be attributed to nonspeci fi c clinical and imaging fi ndings of… read more here.
Keywords: anti; encephalitis; methyl aspartate; anti methyl ... See more keywords
Reproductive experience alters the involvement of N-methyl-D-aspartate receptors in fear extinction, but not fear conditioning, in female Sprague Dawley rats
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DOI: 10.1007/s00213-018-4956-y
Abstract: Recently, evidence has emerged showing that the behavioural and hormonal features of fear extinction are altered as a result of reproductive experience in both rats and humans. The current set of experiments sought to determine… read more here.
Keywords: fear extinction; extinction; methyl aspartate; reproductive experience ... See more keywords
Comparison of N-methyl-d-aspartate receptor antibody assays using live or fixed substrates
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DOI: 10.1007/s00415-020-10329-0
Abstract: The diagnostic criteria for N -methyl- d -aspartate receptor antibody (NMDAR-Ab) encephalitis require the presence of CSF antibodies against the NMDAR, whereas serum antibodies are considered specific only if accompanied by CSF antibodies. Current assays… read more here.
Keywords: receptor antibody; methyl aspartate; cba; aspartate receptor ... See more keywords
Alleviation by GABAB Receptors of Neurotoxicity Mediated by Mitochondrial Permeability Transition Pore in Cultured Murine Cortical Neurons Exposed to N-Methyl-d-aspartate
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DOI: 10.1007/s11064-017-2311-z
Abstract: Mitochondrial permeability transition pore (PTP) is supposed to at least in part participate in molecular mechanisms underlying the neurotoxicity seen after overactivation of N-methyl-d-aspartate (NMDA) receptor (NMDAR) in neurons. In this study, we have evaluated… read more here.
Keywords: methyl aspartate; nmda; neurotoxicity; mitochondrial permeability ... See more keywords
Implication of Genes for the N-Methyl-d-Aspartate (NMDA) Receptor in Substance Addictions
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DOI: 10.1007/s12035-018-0877-3
Abstract: Drug dependence is a chronic brain disease with harmful consequences for both individual users and society. Glutamate is a primary excitatory neurotransmitter in the brain, and both in vivo and in vitro experiments have implicated… read more here.
Keywords: methyl aspartate; implication genes; etiology; nmda receptor ... See more keywords
Memantine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01678-7
Abstract: Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid beta (Aβ) deposits and causes cerebral hemorrhages and dementia in elderly people. Memantine is used in Alzheimer’s disease to inhibit the glutamatergic system by blocking… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; methyl aspartate; degrading enzyme ... See more keywords