Articles with "methyl benzyl" as a keyword



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Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N'-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides.

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Published in 2018 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2017.10.036

Abstract: Three series of 4-hydroxy-N'-[benzylidene/1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides (9-11)a-l were synthesized and unraveled to be highly potent dual inhibitors of monoamine oxidases (MAO-A and MAO-B). All the examined compounds demonstrated IC50 values in lower micro-molar range for both… read more here.

Keywords: carbohydrazide; benzylidene phenylethylidene; methyl benzyl; hydroxy benzylidene ... See more keywords