Cys2His2 zinc finger methyl-CpG binding proteins: Getting a handle on methylated DNA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.012
Abstract: DNA methylation is an essential epigenetic modification involved in the maintenance of genomic stability, preservation of cellular identity, and regulation of the transcriptional landscape needed to maintain cellular function. In an increasing number of disease… read more here.
Keywords: binding proteins; dna; zinc finger; methyl cpg ... See more keywords
The Methyl-CpG Binding Domain 2 and 3 proteins and formation of the Nucleosome Remodeling and Deacetylase complex.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.10.007
Abstract: The Nucleosome Remodeling and Deacetylase (NuRD) complex uniquely combines both deacetylase and remodeling enzymatic activities in a single macromolecular complex. The Methyl-CpG Binding Domain 2 and 3 (MBD2 and MBD3) proteins provide a critical structural… read more here.
Keywords: deacetylase; binding domain; remodeling deacetylase; methyl cpg ... See more keywords
Methyl-CpG-binding domain 3 inhibits stemness of pancreatic cancer cells via Hippo signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112091
Abstract: Methyl-CpG-binding domain 3 (MBD3), as an induced stem cells reprogramming barrier, has an abnormal expression in various prevalent malignancies. However, in pancreatic cancer cell stemness, the roles of MBD3 remain unclear. In our study, the… read more here.
Keywords: methyl cpg; pancreatic cancer; cpg binding; mbd3 ... See more keywords
Expression regulation by a methyl-CpG binding domain in an E. coli based, cell-free TX-TL system.
Sign Up to like & getrecommendations! Published in 2017 at "Physical biology"
DOI: 10.1088/1478-3975/aa5d37
Abstract: Cytosine methylation plays an important role in the epigenetic regulation of eukaryotic gene expression. The methyl-CpG binding domain (MBD) is common to a family of eukaryotic transcriptional regulators. How MBD, a stretch of about 80… read more here.
Keywords: binding domain; methyl cpg; cell free; expression ... See more keywords
Interregulation between fragile X mental retardation protein and methyl CpG binding protein 2 in the mouse posterior cerebral cortex
Sign Up to like & getrecommendations! Published in 2020 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddaa226
Abstract: Abstract Several X-linked neurodevelopmental disorders including Rett syndrome, induced by mutations in the MECP2 gene, and fragile X syndrome (FXS), caused by mutations in the FMR1 gene, share autism-related features. The mRNA coding for methyl… read more here.
Keywords: protein; cerebral cortex; methyl cpg; binding protein ... See more keywords
The impacts of allopolyploidization on Methyl-CpG-Binding Domain (MBD) gene family in Brassica napus
Sign Up to like & getrecommendations! Published in 2022 at "BMC Plant Biology"
DOI: 10.1186/s12870-022-03485-0
Abstract: Background Polyploidization promotes species formation and is widespread in angiosperms. Genome changes dramatically bring opportunities and challenges to plants after polyploidy. Methyl-CpG-Binding Domain (MBD) proteins can recognize and bind to methylation sites and they play… read more here.
Keywords: methyl cpg; mbd; allopolyploidization; mbd genes ... See more keywords
Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007107
Abstract: While schistosomiasis remains a significant health problem in low to middle income countries, it also represents a recently recognised threat to more economically-developed regions. Until a vaccine is developed, this neglected infectious disease is primarily… read more here.
Keywords: mansoni; methyl cpg; smcbx; schistosoma ... See more keywords
Rett syndrome: Methyl-CpG binding protein 2 transformation and phenotypic-genotypic characteristics
Sign Up to like & getrecommendations! Published in 2020 at "Pesquisa Agropecuaria Brasileira"
DOI: 10.19045/bspab.2020.90246
Abstract: Methyl-CpG-binding protein 2 (MECP2) mutation has been coupled to Rett syndrome; X-linked neurological disorder, leading to steady slowing down of neurodevelopment that exclusively affects girls worldwide. As this gene is known for its specific localization… read more here.
Keywords: methyl cpg; phenotypic; rett syndrome; cpg binding ... See more keywords
Cannabidiol prevents methamphetamine-induced neurotoxicity by modulating dopamine receptor D1-mediated calcium-dependent phosphorylation of methyl-CpG-binding protein 2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.972828
Abstract: In the past decade, methamphetamine (METH) abuse has sharply increased in the United States, East Asia, and Southeast Asia. METH abuse not only leads to serious drug dependence, but also produces irreversible neurotoxicity. Currently, there… read more here.
Keywords: dopamine receptor; cbd pretreatment; phosphorylation methyl; methyl cpg ... See more keywords
Genome-Wide Characterization of the Methyl CpG Binding Domain-Containing Proteins in Watermelon and Functional Analysis of Their Roles in Disease Resistance Through Ectopic Overexpression in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.886965
Abstract: Methyl-CPG-Binding Domain (MBD) proteins play important roles in plant growth, development, and stress responses. The present study characterized the MBD families in watermelon and other cucurbit plants regarding the gene numbers and structures, phylogenetic and… read more here.
Keywords: clmbd2; overexpression; expression; methyl cpg ... See more keywords
Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11081216
Abstract: Intrinsic disorder plays an important functional role in proteins. Disordered regions are linked to posttranslational modifications, conformational switching, extra/intracellular trafficking, and allosteric control, among other phenomena. Disorder provides proteins with enhanced plasticity, resulting in a… read more here.
Keywords: disordered regions; methyl cpg; mecp2; stabilization effect ... See more keywords