Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00846
Abstract: Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of synaptic and extrasynaptic GABAA receptors. Herein, we report new SAR insights in a series of 5β-nor-19-pregnan-20-one analogues bearing substituted pyrazoles and triazoles at… read more here.
Keywords: neuroactive steroids; pregnan one; hydroxy methyl; methyl cyano ... See more keywords
Dual Pathways, One Framework: Theoretical Insights into the Benzimidazole × Benzodiazepine Crossroads from o‑Phenylenediamine and 2‑Cyanoacrylate Derivatives
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DOI: 10.1021/acsomega.5c05925
Abstract: Ketene dithioacetals represent a significant class of molecules with a pivotal role in organic synthesis, particularly as versatile building blocks for the development of novel pharmaceutical compounds. We employed density functional theory (DFT) calculations in… read more here.
Keywords: framework theoretical; dihydro benzo; dual pathways; one framework ... See more keywords