Characterization and antimicrobial activity of a 2-O-methyl-β-cyclodextrin inclusion complex containing hexahydro-β-acids
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Science"
DOI: 10.1007/s10853-018-3148-9
Abstract: An inclusion complex of hexahydro-β-acids (HBA) and 2-O-methyl-β-cyclodextrin (M-β-CD) was prepared using the grinding method to improve the water solubility of HBA. Complex formation was assessed using ultraviolet and visible light (UV–Vis) spectroscopy, Fourier transform… read more here.
Keywords: inclusion; methyl cyclodextrin; hexahydro acids; inclusion complex ... See more keywords
Compatibility studies with pharmaceutical excipients for aripiprazole–heptakis (2,6-di-O-methyl)-β-cyclodextrin supramolecular adduct
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-020-09901-7
Abstract: Aripiprazole (ARP) is one of the newest antipsychotic drugs, exhibiting very low aqueous solubility and high lipophilicity. Considering the necessity of improvement of ARP physicochemical properties and its biopharmaceutical profile, cyclodextrin complexation of the drug… read more here.
Keywords: compatibility; cyclodextrin; methyl cyclodextrin; spectroscopy ... See more keywords
Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104752
Abstract: Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no… read more here.
Keywords: methyl cyclodextrin; inhibits d68; perturbing accumulation; lipid rafts ... See more keywords
Effect of Methyl-β-Cyclodextrin on the antimicrobial activity of a new series of poorly water-soluble benzothiazoles.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.12.016
Abstract: The antibacterial activity of the S-unsubstituted- and S-benzyl-substituted-2-mercapto-benzothiazoles 1-4 has been evaluated after complexation with Methyl-β-Cyclodextrin (Me-β-CD) or incorporation in solid dispersions based on Pluronic® F-127 and compared with that of the pure compounds. This… read more here.
Keywords: antimicrobial activity; methyl cyclodextrin; cyclodextrin antimicrobial; activity ... See more keywords
Crystal structures and molecular dynamics studies of the inclusion compounds of β-citronellol in β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.02.037
Abstract: Abstract The crystal structures of the inclusion complexes of the β-citronellol (cl) inβ-Cyclodextrin (β-CD), heptakis(2,6-di-O-methyl)-β-Cyclodextrin (DM-β-CD) and heptakis(2,3,6-tri-O-methyl)-β-Cyclodextrin (TM-β-CD) have being investigated by X-ray crystallography. The cl/β-CD inclusion complex crystallizes in the P1space group forming… read more here.
Keywords: cyclodextrin; inclusion; cyclodextrin heptakis; methyl cyclodextrin ... See more keywords
Inhibition of Epigallocatechin-3-gallate/Protein Interaction by Methyl-β-cyclodextrin in Myofibrillar Protein Emulsion Gels under Oxidative Stress.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b00275
Abstract: Nowadays, natural antioxidants abundant in polyphenols have been widely used to substitute synthetic antioxidants in meat products. In general, high doses of natural antioxidants are required to provide comparative antioxidant effects as synthetic antioxidants. Noticeably,… read more here.
Keywords: protein; oxidative stress; methyl cyclodextrin; epigallocatechin gallate ... See more keywords
Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43947-4
Abstract: Methyl-β-cyclodextrin (MCD), an established pharmacological excipient, depolymerizes the actin cytoskeleton. In this work, we investigated the effect of MCD-mediated actin depolymerization on various cellular phenotypes including traction force, cell stiffness, focal adhesions, and intracellular drug… read more here.
Keywords: actin; methyl cyclodextrin; targeting agents; cancer ... See more keywords
Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s133482
Abstract: Mitophagy is the specific autophagic elimination system of mitochondria, which regulates cellular survival via the removal of damaged mitochondria. Recently, we revealed that folate-appended methyl-β-cyclodextrin (FA-M-β-CyD) provides selective antitumor activity in folate receptor-α (FR-α)-expressing cells… read more here.
Keywords: induction mitophagy; mitophagy; methyl cyclodextrin; antitumor activity ... See more keywords