Efficient preparative separation of 6-(4-aminophenyl)-5-methyl-4, 5-dihydro-3(2H)-pyridazinone enantiomers on polysaccharide-based stationary phases in polar organic solvent chromatography and supercritical fluid chromatography.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of separation science"
DOI: 10.1002/jssc.201900253
Abstract: 6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone is a key synthetic intermediate for cardiotonic agent levosimendan. Very few studies address the use of chiral stationary phases in chromatography for the enantioseparation of this intermediate. This study presents two efficient preparative methods… read more here.
Keywords: chromatography; polar organic; aminophenyl methyl; dihydro pyridazinone ... See more keywords
Visible-light driven regioselective synthesis, characterization and binding studies of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines with DNA and BSA using biophysical and computational techniques
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DOI: 10.1038/s41598-021-01037-4
Abstract: In recent times, fused azaheterocycles emerged as impressive therapeutic agents. Binding studies of such azaheterocycles with biomolecules is an important subject for pharmaceutical and biochemical studies aiming at the design and development of new drugs.… read more here.
Keywords: aroyl methyl; methyl dihydro; binding studies; thiazolo pyrimidines ... See more keywords
(4-Nitrophenyl)methyl 2,3-dihydro-1H-pyrrole-1-carboxylate: crystal structure and Hirshfeld analysis
Sign Up to like & getrecommendations! Published in 2018 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989018002451
Abstract: The title compound has a ‘banana’ shape, with the dihedral angle formed by the outer rings being 8.30 (7)°. In the crystal, the three-dimensional architecture features nitrobenzene-C—H⋯O(carbonyl), pyrrole-C—H⋯O(nitro), π(pyrrole)—π(nitrobenzene) and nitro-O⋯π(pyrrole) interactions. read more here.
Keywords: carboxylate crystal; dihydro pyrrole; crystal structure; nitrophenyl methyl ... See more keywords
The crystal structures and Hirshfeld surface analyses of four 3,5-diacetyl-2-methyl-2,3-dihydro-1,3,4-thiadiazol-2-yl derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989019011915
Abstract: The crystal structures of four 3,5-diacetyl-2-methyl-2,3-dihydro-1,3,4-thiadiazol-2-yl derivatives, viz. 4-phenyl benzoate, 4-phenyl isobutyrate, 4-phenyl propionate and 4-phenyl cinnamate, are described and the intermolecular contacts in the crystals are analysed using Hirshfeld surface analysis and two-dimensional fingerprint… read more here.
Keywords: four diacetyl; methyl dihydro; thiadiazol derivatives; crystal structures ... See more keywords