Mitochondrial transport and metabolism of the major methyl donor and versatile cofactor S‐adenosylmethionine, and related diseases: A review†
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DOI: 10.1002/iub.2658
Abstract: S‐adenosyl‐L‐methionine (SAM) is a coenzyme and the most commonly used methyl‐group donor for the modification of metabolites, DNA, RNA and proteins. SAM biosynthesis and SAM regeneration from the methylation reaction product S‐adenosyl‐L‐homocysteine (SAH) take place… read more here.
Keywords: major methyl; sam; metabolism major; transport metabolism ... See more keywords
Methyl Donor Ameliorates CCl4‐Induced Nephrotoxicity by Inhibiting Oxidative Stress, Inflammation, and Fibrosis Through the Attenuation of Kidney Injury Molecule 1 and Neutrophil Gelatinase‐Associated Lipocalin Expression
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DOI: 10.1002/jbt.70188
Abstract: Carbon tetrachloride (CCl4), a volatile organic compound, is harmful to multi‐organs, including the liver, lungs, muscles, and kidneys. Methyl donors, such as methionine, choline, betaine, and folic acid, are vital to one‐carbon metabolism and have… read more here.
Keywords: methyl donor; ccl4 induced; induced nephrotoxicity; oxidative stress ... See more keywords
Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype
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DOI: 10.1007/s00394-017-1411-5
Abstract: PurposeDNA methylation plays a fundamental role in the epigenetic control of carcinogenesis and is, in part, influenced by the availability of methyl donors obtained from the diet. In this study, we developed an in-vitro model… read more here.
Keywords: cell; methyl donor; donor depletion;
Habitual dietary methyl donor’s intake and metabolic profile in obese individuals: a cross-sectional study
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DOI: 10.1038/s41598-024-75388-z
Abstract: Considering the role of dietary methyl donor (DMD) in numerous biochemical processes, we hypothesized that DMD could play an important role in metabolic syndrome such as hyperlipidemia, hypertension, insulin resistance, and appetite in obese individuals.… read more here.
Keywords: methyl donor; obese individuals; cross sectional; sectional study ... See more keywords
P-011 Maternal gestational methyl donor deficiency affects reproductive development and fertility of mice offspring
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DOI: 10.1093/humrep/deae108.390
Abstract: Is maternal methyl donor deficiency during gestation affects offspring’s reproductive health at adulthood? Maternal gestational methyl donor deficiency affects reproductive development and fertility of F1 offspring and also leads to increased post implantation loss Reproductive… read more here.
Keywords: methyl donor; development; donor deficiency; histology ... See more keywords
The Effect of Dietary Methyl-Donor Intake and Other Lifestyle Factors on Cancer Patients in Hungary
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DOI: 10.3390/cancers14184432
Abstract: Simple Summary The incidence of cancer has been increasing worldwide and, along with inflammation-related diseases, a significant number of cases could be prevented by appropriate lifestyle routines. Methyl-donors are macronutrients that are important in achieving… read more here.
Keywords: cancer; cancer patients; methyl donor; patient ... See more keywords
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome
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DOI: 10.3390/nu11030608
Abstract: DNA methylation is an epigenetic mechanism that is essential for regulating gene transcription. However, aberrant DNA methylation, which is a nearly universal finding in cancer, can result in disturbed gene expression. DNA methylation is modified… read more here.
Keywords: methylation; methyl donor; cancer; dna methylation ... See more keywords
Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies
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DOI: 10.3748/wjg.v29.i7.1219
Abstract: BACKGROUND Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). However, whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still unclear. AIM To… read more here.
Keywords: influence methyl; methyl donor; crc; observational studies ... See more keywords
Perinatal high methyl donor alters gene expression in IGF system in male offspring without altering DNA methylation
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DOI: 10.4155/fsoa-2016-0077
Abstract: Aim: To investigate the effect of a protein restriction and a supplementation with methyl donor nutrients during fetal and early postnatal life on the expression and epigenetic state of imprinted genes from the IGF system.… read more here.
Keywords: methylation; methyl donor; expression; gene ... See more keywords