Pd-catalyzed γ-C(sp3)-H Fluorination of Free Amines.
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DOI: 10.1021/jacs.9b13537
Abstract: The first example of free amine γ-C(sp3)-H fluorination is realized using 2-hydroxynicotinaldehyde as the transient directing group. A wide range of cyclohexyl and linear aliphatic amines could be fluorinated selectively at the γ-methyl and methylene… read more here.
Keywords: methyl fluorination; step; sp3 fluorination; fluorination ... See more keywords