Electrocatalytic Intermolecular C(sp3)-H/N-H Coupling of Methyl N-Heteroaromatics with Amines and Amino Acids: Access to Imidazo-Fused N-Heterocycles.
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DOI: 10.1021/acs.orglett.8b02578
Abstract: An efficient NH4I-mediated intermolecular annulation of methyl N-heteroaromatics with amines/amino acids was developed by virtue of anodic oxidation, providing a variety of functionalized imidazo-fused N-heterocycles with good to excellent yields. The practicality of this protocol… read more here.
Keywords: amino acids; amines amino; fused heterocycles; imidazo fused ... See more keywords
Ni-Catalyzed dehydrogenative coupling of primary and secondary alcohols with methyl-N-heteroaromatics
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DOI: 10.1039/c8qo00764k
Abstract: Here we report the first base-metal catalyzed dehydrogenative coupling of primary (aromatic, heteroaromatic, and aliphatic) and secondary alcohols with methyl-N-heteroaromatics to form various C(sp3)-alkylated N-heteroaromatics. The reaction is enabled by Earth abundant, non-precious NiBr2 as… read more here.
Keywords: coupling primary; catalyzed dehydrogenative; methyl heteroaromatics; secondary alcohols ... See more keywords