Synthesis and aminomethylation of regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-018-2360-5
Abstract: The regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones were synthesized. Aminomethylation by the action of aminals of secondary amines was investigated. It was shown that the reaction proceeds selectively with the formation of 7-aminomethyl-6-hydroxy-4-methyl- and 5-aminomethyl-4-hydroxy-6-methylaurones, respectively. The… read more here.
Keywords: hydroxy methylaurones; methyl hydroxy; regioisomeric hydroxy; hydroxy methyl ... See more keywords
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112070
Abstract: Management of moderate to severe pain by clinically used opioid analgesics is associated with a plethora of side effects. Despite many efforts have been dedicated to reduce undesirable side effects, moderate progress has been made.… read more here.
Keywords: hydroxy methoxyphenyl; potent analgesic; methyl hydroxy; dimethylamino methyl ... See more keywords
Practical synthesis of methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)-heptanoate
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DOI: 10.1016/j.jscs.2017.01.004
Abstract: Abstract The key intermediate of misoprostol, methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)-heptanoate was prepared from commercially available suberic acid in 40% yield over five steps. The key step involved a ZnCl 2 catalyzed Friedel-Crafts reaction between furan and 2,9-oxonanedione.… read more here.
Keywords: hydroxy oxocyclopent; oxocyclopent heptanoate; methyl hydroxy;
New Tridentate Schiff Base, Product of Condensation of 4-Methyl-7-hydroxy-8-formylcoumarin and N-Aminomercaptotriazole: Synthesis, Structure, and Complex Formation
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DOI: 10.1134/s1070363218070150
Abstract: A new Schiff base was prepared by the reaction of 4-methyl-7-hydroxy-8-formylcoumarin with N-aminomercaptotriazole. In solution and in solid phase the compound was shown to exist in the thione form. The compound reacts with Cu(II), Ni(II),… read more here.
Keywords: hydroxy formylcoumarin; formylcoumarin aminomercaptotriazole; methyl hydroxy; schiff base ... See more keywords
Methyl 4-Hydroxy-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylate and Its Analogs Modified in the Benzene Moiety of the Molecule as New Analgesics
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DOI: 10.3390/scipharm88010010
Abstract: In order to identify new regularities of the “structure–analgesic activity” relationship in the series of 2,1-benzothiazine derivatives, the synthesis of methyl 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate and a group of its analogs substituted in the benzene moiety of the… read more here.
Keywords: molecule; moiety molecule; benzothiazine; benzene moiety ... See more keywords