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   Articles with "methyl nitrosourea" as a keyword



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Structural, energetics and vibrational analyses of monomeric and dimeric forms of 2-deoxy-2-(3-methyl-3-nitrosourea)-1-D-glucopyranose

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recommendations! Published in 2020 at "Journal of Molecular Structure"

DOI: 10.1016/j.molstruc.2020.129588

Abstract: Abstract The quantum chemical calculations and IR & Raman spectra have been used to characterize the structural, energetics and vibrational properties of 2-deoxy-2-(3-methyl-3-nitrosourea)-1-D-glucopyranose (streptozotocin, STZ), which is widely used in diabetes research. The two conformers… read more here.

Keywords: nitrosourea glucopyranose; structural energetics; monomeric dimeric; energetics vibrational ... See more keywords
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N-Methyl-N-nitrosourea Induced 3'-Glutathionylated DNA-Cleavage Products in Mammalian Cells.

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recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c02003

Abstract: Apurinic/apyrimidinic (AP) sites, that is, abasic sites, are among the most frequently induced DNA lesions. Spontaneous or DNA glycosylase-mediated β-elimination of the 3'-phosphoryl group can lead to strand cleavages at AP sites to yield a… read more here.

Keywords: induced glutathionylated; nitrosourea induced; dna; ddr dna ... See more keywords
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The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline.

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recommendations! Published in 2017 at "International journal of ophthalmology"

DOI: 10.18240/ijo.2017.10.03

Abstract: AIM To investigate the effects of hydrogen-rich saline (HRS) on microglia activation and Sirtuin type 1 (Sirt1) in rats with N-methyl-N-nitrosourea (MNU)-induced retinitis pigmentosa (RP). METHODS Rats were divided into norm (N) group, model (M)… read more here.

Keywords: rich saline; mnu induced; group; hydrogen rich ... See more keywords

Preventive effect of Oenothera rosea on N-methyl-N-nitrosourea-(NMU) induced gastric cancer in rats

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recommendations! Published in 2017 at "Clinical and Experimental Gastroenterology"

DOI: 10.2147/ceg.s142515

Abstract: Background Currently, gastric cancer (GC) is considered a public health problem worldwide. Using medicinal plants for the prevention of chronic diseases such as cancer constitutes new alternatives in traditional medicine. Oenothera rosea (OR) could be… read more here.

Keywords: oenothera rosea; gastric cancer; nitrosourea nmu; effect ... See more keywords

Adeno-associated virus-mediated neuroglobin overexpression ameliorates the N-methyl-N-nitrosourea-induced retinal impairments: a novel therapeutic strategy against photoreceptor degeneration

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recommendations! Published in 2017 at "Therapeutics and Clinical Risk Management"

DOI: 10.2147/tcrm.s144822

Abstract: Retinal degeneration (RD) is a heterogeneous group of inherited dystrophies leading to blindness. The N-methyl-N-nitrosourea (MNU)-administered mouse is used as a pharmacologically induced RD animal model in various therapeutic investigations. The present study found the… read more here.

Keywords: overexpression; associated virus; mnu administered; adeno associated ... See more keywords
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Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway

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recommendations! Published in 2022 at "Biomedicines"

DOI: 10.3390/biomedicines10020311

Abstract: N-methyl-N-nitrosourea (NMU) is widely used to model oxidative stress and inflammation mediated retinal neurodegeneration. Wedelolactone (WD) is known to have antioxidant, anti-inflammatory, and neuroprotective roles. This study tested the therapeutic potential of WD in NMU-induced… read more here.

Keywords: retinal neurodegeneration; induced retinal; neurodegeneration; wedelolactone ... See more keywords
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Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice

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recommendations! Published in 2017 at "World Journal of Gastroenterology"

DOI: 10.3748/wjg.v23.i23.4233

Abstract: AIM To investigate the inhibitory effect of Liuwei Dihuang Pill (LDP) on gastric tumorigenesis induced by N-methyl-N-nitrosourea (MNU) in diabetic mice. METHODS Four-week-old mice were divided into four groups: A, 12 db/m mice treated with… read more here.

Keywords: gastric tumorigenesis; mice treated; mice; dihuang pill ... See more keywords