Spectral characterization, DFT, docking and cytotoxicity of N-benzyl-4,5-dihydro-3-methyl-5-oxo-1H-pyrazole-4-carbothioamide and its metal complexes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130020
Abstract: Abstract A new ligand N-benzyl-4,5-dihydro-3-methyl-5-oxo-1H-pyrazole-4-carbothioamide (H2L) and some of its divalent metal complexes were synthesized. Elemental analyses, mass spectra (MS), 1H and 13Cnuclear magnetic resonance, electronparamagnetic resonance (EPR), infrared spectra (IR), ultra-violet and visible spectra,… read more here.
Keywords: benzyl dihydro; cytotoxicity; dihydro methyl; metal ... See more keywords
Effect of annealing and UV irradiation on structural and optical properties of 6-(3,4 Dimethoxyphenyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro1Hpyrazolo[4,3-b]-5-carbonitrile thin films
Sign Up to like & getrecommendations! Published in 2017 at "Optical Materials"
DOI: 10.1016/j.optmat.2017.04.065
Abstract: Abstract 6-(3,4 Dimethoxyphenyl)-1-methyl-3-oxo-2-phenyl-2,3 dihydro1Hpyrazolo[4,3-b]-5-carbonitrile, DMOPC, is a newly synthesized organic compound. DMOPC showed polycrystalline structure and crystallizes in monoclinic crystal system. The deposited thin films showed nanocrystals embedded in amorphous medium. The optical constants of… read more here.
Keywords: thin films; phenyl dihydro1hpyrazolo; dimethoxyphenyl methyl; methyl oxo ... See more keywords
Enantioselective benzylation of methyl 4-oxo-3-piperidinecarboxylate with cinchona alkaloids phase-transfer catalysts
Sign Up to like & getrecommendations! Published in 2018 at "Synthetic Communications"
DOI: 10.1080/00397911.2018.1496259
Abstract: Abstract The asymmetric benzylation of methyl 4-oxo-3-piperidinecarboxylate has been investigated, and methyl (R)-1,3-dibenzyl-4-oxopiperidine-3-carboxylate (3c) was obtained by using a phase-transfer catalyst O-allyl-N-9-anthracenemethyl-cindexnine bromide (1k). This synthetic method has the advantages of cheap materials, mild reaction… read more here.
Keywords: methyl oxo; phase transfer; benzylation methyl; oxo piperidinecarboxylate ... See more keywords
Ethyl 2-(4-benzyl-3-methyl-6-oxo-1,6-dihydropyridazin-1-yl)acetate: crystal structure and Hirshfeld surface analysis
Sign Up to like & getrecommendations! Published in 2019 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s205698901900241x
Abstract: In the title molecule, the oxopyridazinyl ring is N-bound to an ethylacetate group with benzyl and methyl groups substituted at adjacent C atoms. In the molecular packing, methylene-C—H⋯O(ring carbonyl) and N(pyridazinyl) interactions result in the… read more here.
Keywords: benzyl methyl; dihydropyridazin acetate; methyl oxo; ethyl benzyl ... See more keywords
Synthesis and Luminescence and Ionochromic Properties of 9-Hydroxy-1-methyl-3-oxo-3H-benzo[f]chromene8-carbaldehyde Imines and Hydrazones
Sign Up to like & getrecommendations! Published in 2020 at "Russian Journal of General Chemistry"
DOI: 10.1134/s107036322002005x
Abstract: Formylation of 9-hydroxy-1-methyl-3H-benzo[f]chromen-3-one with hexamethylenetetramine in acetic acid afforded 9-hydroxy-1-methyl-3-oxo-3H-benzo[f]chromene-8-carbaldehyde which was converted to the corresponding aldehyde imines and aroylhydrazones. According to the 1H NMR and UV spectral data, 9-hydroxy-1-methyl-3-oxo-3H-benzo[f]chromene-8-carbaldehyde imines in solution exist as… read more here.
Keywords: hydroxy methyl; oxo benzo; methyl oxo; methyl ... See more keywords
Exploring the Effects of Chirality of 5-methyl-5-[4-(4-oxo-3H-quinazolin-2-yl) phenyl]imidazolidine-2,4-dione and its Derivatives on the Oncological Target Tankyrase 2. Atomistic Insights.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666230330084017
Abstract: BACKGROUND Tankyrases (TNKS) are homomultimers existing in two forms, viz. TNKS1 and TNKS2. TNKS2 plays a pivotal role in carcinogenesis by activating the Wnt//β-catenin pathway. TNKS2 has been identified as a suitable target in oncology… read more here.
Keywords: phenyl imidazolidine; quinazolin phenyl; imidazolidine dione; oxo quinazolin ... See more keywords
N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agents—In Silico and In Vitro Evaluation
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16010131
Abstract: Herein, we report the experimental evaluation of the antimicrobial activity of seventeen new (Z)-methyl 3-(4-oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylate derivatives. All tested compounds exhibited antibacterial activity against eight Gram-positive and Gram-negative bacteria. Their activity exceeded those of ampicillin as… read more here.
Keywords: thioxothiazolidin ylidene; activity; oxo thioxothiazolidin; ylidene methyl ... See more keywords
One-pot synthesis of substituted pyrrolo[3,4-b]pyridine-4,5-diones based on the reaction of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamide with amines
Sign Up to like & getrecommendations! Published in 2019 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.15.277
Abstract: The condensation of primary amines with N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamides was explored. Thus, a previously unknown recyclization of the starting material was observed in acidic ethanol in the presence of an amine, which provided the corresponding dihydropyrrolone derivative… read more here.
Keywords: pyran oxo; hydroxy methyl; oxo arylethyl; methyl oxo ... See more keywords