Investigation of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02542-1
Abstract: Herein, we report the studies of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid. General methods for the synthesis of 6-methyl-3,4-dihydropyrano[3,2-b]pyran-2,8-diones, 3-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)propanoic acid amides and esters, as well as 7-oxo-7H-furo[3,2-b]pyran-3-ylacetic acids were… read more here.
Keywords: methyl; multicomponent reaction; hydroxy methyl; reaction hydroxy ... See more keywords
Condensation of 5-hydroxy-2-methyl-4H-pyran-4-one with arylglyoxals. Synthesis and properties of 2-aryl-1-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)ethane-1,2-diones
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DOI: 10.1007/s11172-018-2301-6
Abstract: A convenient method was developed for the synthesis of previously unknown 1,2-diketones, based on the condensation of 5-hydroxy-2-methyl-4H-pyran-4-one with arylglyoxals. The study demonstrated the possibility of using these compounds to synthesize nitrogen-containing hetero cyclic systems… read more here.
Keywords: methyl; hydroxy methyl; condensation hydroxy; methyl pyran ... See more keywords
Caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one isolated from the leaves of Olinia usambarensis attenuates LPS-induced inflammatory mediators by inactivating AP-1 and NF-κB.
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DOI: 10.1016/j.cbi.2019.06.031
Abstract: We have previously reported the isolation of four compounds, caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one (CDMP), olinioside, caffeic acid and 3-hydroxylup-12-en-28-oic acid, from the leaves of Olinia usambarensis. Here, we evaluated the inhibitory effects of these compounds on lipopolysaccharide (LPS)-induced… read more here.
Keywords: caffeoyloxy dihydro; lps induced; dihydro methyl; inflammatory mediators ... See more keywords
Design, synthesis and biological evaluation of 2-substituted 3-hydroxy-6-methyl-4H-pyran-4-one derivatives as Pseudomonas aeruginosa biofilm inhibitors.
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DOI: 10.1016/j.ejmech.2018.09.041
Abstract: Drug-resistant bacteria associated with biofilm formation are rapidly on the rise, requiring novel therapeutic options to combat biofilm induced drug-resistance. In this study, a class of 3-hydroxy-2-(phenylhydroxy-methyl)-6-methyl-4H-pyran-4-one derivatives (1a-1e) were found by screening of an… read more here.
Keywords: methyl; pseudomonas aeruginosa; one derivatives; methyl pyran ... See more keywords