Crystallographic studies of piperazine derivatives of 3-methyl-5-spirofluorenehydantoin in search of structural features of P-gp inhibitors.
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DOI: 10.1107/s2053229621006756
Abstract: 5-Spirofluorenehydantoin derivatives show efflux modulating, cytotoxic and antiproliferative effects in sensitive and resistant mouse T-lymphoma cells. In order to extend the knowledge available about the pharmacophoric features responsible for the glycoprotein P (P-gp) inhibitory properties… read more here.
Keywords: crystallographic studies; derivatives methyl; spirofluorenehydantoin search; methyl spirofluorenehydantoin ... See more keywords