Widespread Sterol Methyltransferase Participates in the Biosynthesis of Both C4α- and C4β-Methyl Sterols
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DOI: 10.1021/jacs.2c01401
Abstract: The 4-methyl steranes serve as molecular fossils and are used for studying both eukaryotic evolution and geological history. The occurrence of 4α-methyl steranes in sediments has long been considered evidence of products of partial demethylation… read more here.
Keywords: methyl steranes; sterol methyltransferase; methyl; methyl sterols ... See more keywords
Metabolism and Biological Activities of 4-Methyl-Sterols
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DOI: 10.3390/molecules24030451
Abstract: 4,4-Dimethylsterols and 4-methylsterols are sterol biosynthetic intermediates (C4-SBIs) acting as precursors of cholesterol, ergosterol, and phytosterols. Their accumulation caused by genetic lesions or biochemical inhibition causes severe cellular and developmental phenotypes in all organisms. Functional… read more here.
Keywords: metabolism biological; activities methyl; methyl sterols; biological activities ... See more keywords