Design, synthesis, anticonvulsant evaluation and docking study of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothioureas.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.02.009
Abstract: In this paper, we report the synthesis of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothiourea derivatives (4a-y) carrying active pharmacophores essential for anticonvulsant activity. The anticonvulsant activity was evaluated in vivo by maximal electroshock (MES) test and subcutaneous pentylenetetrazole… read more here.
Keywords: thiazol ylcarbamoyl; methyl substituted; benzo thiazol; substituted phenyl ... See more keywords
Reactivity of hemilabile pyridyl- and methyl-substituted pyrimidylselenolates with [MCl2(dppf)] (M = Pd, pt; dppf = bis(diphenylphisphino)ferrocene)
Sign Up to like & getrecommendations! Published in 2018 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.03.034
Abstract: Abstract The bis(diphenylphisphino)ferrocene (dppf) derived palladium analogue of [PdCl2(dppf)] on reaction with the sodium salt of pyridyl/pyrimidyl selenolate yielded mononuclear cis configured complex [Pd(SeAr)2(dppf)] (Ar = C5H4N, C4H(4,6-Me)2N2), as did the platinum precursor [PtCl2(dppf)] with methyl substituted… read more here.
Keywords: bis diphenylphisphino; diphenylphisphino ferrocene; methyl substituted; dppf ... See more keywords
Insights into the Coordination Behavior of Methyl-Substituted Phosphinic Acids with Actinides.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c01287
Abstract: The electronic structure and complexation behavior of methyl-substituted phosphinic acids with U(VI) and Pu(IV) were explored by applying quantum chemical methods. In contrast to Ingold's classification, our results indicate that the methyl group is electron-withdrawing,… read more here.
Keywords: substituted phosphinic; complexation; behavior methyl; methyl substituted ... See more keywords
Metal-Free Radical Annulation of Oxygen-Containing 1,7-Enynes: Configuration-Selective Synthesis of (E)-3-((Arylsulfonyl)methyl)-4-Substituted Arylidenechromene Derivatives.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03946
Abstract: A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction of oxygen-containing 1,7-enynes with thiosulfonates has been developed. The reaction shows broad substrate scope, wide functional group tolerance, and… read more here.
Keywords: arylsulfonyl methyl; synthesis arylsulfonyl; radical annulation; free radical ... See more keywords
Phenazasiline/Spiroacridine Donor Combined with Methyl-Substituted Linkers for Efficient Deep Blue Thermally Activated Delayed Fluorescence Emitters.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b20009
Abstract: Phenazasiline, a sp3 hybridized silicon-bridged diphenylamine, is a promising donor moiety for deep-blue TADF emitters because of its deep highest occupied molecular orbital, high triplet level of 3.1 eV, and orthogonal connection with acceptor moieties.… read more here.
Keywords: deep blue; efficient deep; tadf emitters; methyl substituted ... See more keywords
The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases.
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.3c00059
Abstract: The wide spread of carbapenem-hydrolyzing β-lactamases in Gram-negative bacteria has diminished the utility of the last-resort carbapenem antibiotics, significantly narrowing the available therapeutic options. In the Enterobacteriaceae family, which includes many important clinical pathogens such… read more here.
Keywords: substituted carbapenem; oxa type; methyl substituted; producing oxa ... See more keywords
Some Features of the Reaction of 6-Methyl-2S-substituted Pyrimidin-4-ols with the Vilsmeier–Haack Reagent
Sign Up to like & getrecommendations! Published in 2020 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363220040301
Abstract: Abstract Formylation of 6-methyl-2 S -substituted pyrimidin-4-ols under the conditions of the Vilsmeier–Haack reaction leads to the formation of nucleophilic substitution products of the hydroxyl group. The formation of the expected formylation products does not… read more here.
Keywords: methyl substituted; substituted pyrimidin; pyrimidin ols; vilsmeier haack ... See more keywords
Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s131753
Abstract: This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactones. The newly synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C-NMR, mass spectrometry, and elemental analysis.… read more here.
Keywords: novel methoxy; apoptosis; substituted cis; methyl substituted ... See more keywords
Vanadium(IV) Complexes with Methyl-Substituted 8-Hydroxyquinolines: Catalytic Potential in the Oxidation of Hydrocarbons and Alcohols with Peroxides and Biological Activity
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26216364
Abstract: Methyl-substituted 8-hydroxyquinolines (Hquin) were successfully used to synthetize five-coordinated oxovanadium(IV) complexes: [VO(2,6-(Me)2-quin)2] (1), [VO(2,5-(Me)2-quin)2] (2) and [VO(2-Me-quin)2] (3). Complexes 1–3 demonstrated high catalytic activity in the oxidation of hydrocarbons with H2O2 in acetonitrile at 50… read more here.
Keywords: oxidation; oxidation hydrocarbons; substituted hydroxyquinolines; methyl substituted ... See more keywords