Design, synthesis and biological evaluation of 7-(5-((substituted - amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4'-piperidin]-4-one hydrochloride analogues as anticancer agents.
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DOI: 10.1016/j.bioorg.2021.104865
Abstract: A series of thirty-one novel 7-(5-((amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4'-piperidin]-4-one hydrochloride analogues (Cst 1 - 31) have been designed, synthesized and characterized by 1H NMR, 13C NMR and MS spectral analysis. Here, we evaluated the anticancer potential and biological… read more here.
Keywords: spiro chroman; piperidin one; thiophen spiro; chroman piperidin ... See more keywords
Novel thiophene-benzothiazole derivative azomethine and amine compounds: Microwave assisted synthesis, spectroscopic characterization, solvent effects on UV–Vis absorption and DFT studies
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DOI: 10.1016/j.molstruc.2020.128354
Abstract: Abstract In this study, the novel thiophene-benzothiazole derivative azomethine compounds [(2-((benzo[d]thiazol-2-ylimino)methyl)-4-(thiophen-2-yl)phenol (3a), 2-(((6-methylbenzo[d]thiazol-2-yl)imino)methyl)-4-(thiophen-2-yl)phenol (3b) and 2-(((6-methoxybenzo[d]thiazol-2-yl)imino)methyl)-4-(thiophen-2-yl)phenol (3c)] were successfully synthesized in excellent yields by using conventional heating and microwave assisted synthesis methods. In addition, the… read more here.
Keywords: thiophene benzothiazole; thiophen phenol; methyl thiophen;