Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05273-5
Abstract: AbstractRationaleThe catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human brain.ObjectiveThis study was designed to evaluate the effect of (1) a functional polymorphism and… read more here.
Keywords: methyl transferase; delta tetrahydrocannabinol; study; acute response ... See more keywords
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01247
Abstract: Key epitranscriptomic players have been increasingly characterized for their structural features and their involvement in several diseases. Accordingly, the design and synthesis of novel epitranscriptomic modulators have started opening a glimmer for drug discovery. m6A… read more here.
Keywords: mettl16; like protein; methyl transferase; transferase like ... See more keywords
Effects of Catechol O-Methyl Transferase Inhibition on Anti-Inflammatory Activity of Luteolin Metabolites.
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DOI: 10.1111/1750-3841.13620
Abstract: Although luteolin is known to have potent anti-inflammatory activities, much less information has been provided on such activities of its hepatic metabolites. Luteolin was subjected to hepatic metabolism in HepG2 cells either without or with… read more here.
Keywords: anti inflammatory; methyl transferase; luteolin metabolites; catechol methyl ... See more keywords
Nicotinamide N-methyl transferase and cancer-associated thrombosis: insights to prevention and management.
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DOI: 10.2217/epi-2023-0078
Abstract: Nicotinamide metabolism is important in carcinogenesis. Nicotinamide affects the cellular methyl pool, thus affecting DNA and histone methylation and gene expression. Cancer cells have increased expression of nicotinamide N-methyl transferase (NNMT), the key enzyme in… read more here.
Keywords: associated thrombosis; methyl transferase; nicotinamide methyl; cancer associated ... See more keywords
1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action against Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092816
Abstract: Two analogues of tolcapone where the nitrocatechol group has been replaced by a 1-hydroxy-2(1H)-pyridinone have been designed and synthesised. These compounds are expected to have a dual mode of action both beneficial against Parkinson’s disease:… read more here.
Keywords: parkinson disease; hydroxy pyridinone; methyl transferase; catechol methyl ... See more keywords