α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Journal"
DOI: 10.1042/bcj20210100
Abstract: α-Methyl-L-tryptophan (α-MLT) is currently in use as a tracer in its 11C-labeled form to monitor the health of serotonergic neurons in humans. In the present study, we found this compound to function as an effective… read more here.
Keywords: weight loss; obesity; loss agent; methyl tryptophan ... See more keywords
Tumor microenvironment-responsive micelles assembled from a prodrug of mitoxantrone and 1-methyl tryptophan for enhanced chemo-immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Drug Delivery"
DOI: 10.1080/10717544.2023.2182254
Abstract: Abstract Mitoxantrone (MX) can induce the immunogenic-cell death (ICD) of tumor cells and activate anti-tumor immune responses. However, it can also cause high expression of indole amine 2, 3-dioxygenase (IDO) during ICD, leading to T-cell… read more here.
Keywords: methyl tryptophan; mitoxantrone; tumor microenvironment; enhanced chemo ... See more keywords
PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase
Sign Up to like & getrecommendations! Published in 2019 at "Nanomaterials"
DOI: 10.3390/nano9050719
Abstract: Indoleamine 2,3-dioxygenase (IDO) is an immunomodulating enzyme that is overexpressed in many cancers with poor prognosis. IDO suppresses T cell immunity by catabolizing tryptophan into kynurenine (KYN), which induces apoptosis in T effector cells and… read more here.
Keywords: based polymeric; methyl tryptophan; peg poly; indoleamine dioxygenase ... See more keywords
Synthesis of 5-[18F]Fluoro-α-methyl Tryptophan: New Trp Based PET Agents
Sign Up to like & getrecommendations! Published in 2017 at "Theranostics"
DOI: 10.7150/thno.19371
Abstract: Indoleamine 2,3-dioxygenase (IDO1) plays a special role in the biology of various cancer types, because it breaks down the essential amino acid tryptophan for immune cell activation. Upregulation of IDO1 significantly correlates with the number… read more here.
Keywords: based pet; synthesis 18f; 18f fluoro; methyl tryptophan ... See more keywords