Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases
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DOI: 10.1002/jcb.25967
Abstract: N6‐methyladenosine (m6A) modification is an abundant and conservative RNA modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3′ untranslated regions (UTRs) and near the stop codons of mRNA. Diverse strategies have… read more here.
Keywords: methyladenosine m6a; m6a modification; rna processing; m6a ... See more keywords
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts
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DOI: 10.1038/s41593-018-0173-6
Abstract: A localized transcriptome at the synapse facilitates synapse-, stimulus- and transcript-specific local protein synthesis in response to neuronal activity. While enzyme-mediated mRNA modifications are known to regulate cellular mRNA turnover, the role of these modifications… read more here.
Keywords: methyladenosine m6a; synaptic methyladenosine; m6a epitranscriptome; m6a ... See more keywords
Signatures and Prognostic Values of N6-methyladenosine (m6A) - related Immune Genes in Bladder Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1937910
Abstract: In recent years, genes associated with N6-methyladenosine (m6A) modification were found to participate in modulation of multiple tumor biological processes. Concomitantly, the significantly complicated dual effects of tumor microenvironment have been observed on cancer progression.… read more here.
Keywords: methyladenosine m6a; m6a related; cancer; immune genes ... See more keywords
The effect of N6-methyladenosine (m6A) factors on the development of acute respiratory distress syndrome in the mouse model
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DOI: 10.1080/21655979.2022.2049473
Abstract: ABSTRACT Acute respiratory distress syndrome (ARDS) can cause loss of alveolar-capillary membrane integrity and life-threatening immune responses. The underlying molecular mechanisms of ARDS remain unclear. N6-methyladenosine (m6A)-RNA modification plays an important part in many biological… read more here.
Keywords: respiratory distress; expression; distress syndrome; methyladenosine m6a ... See more keywords
N6-methyladenosine (m6A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1
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DOI: 10.1080/21655979.2022.2068920
Abstract: ABSTRACT N6-methyladenosine (m6A) modification acts as the most prevalent internal modification in eukaryotic mRNA. Emerging evidence shows the critical biological roles of m6A key enzymes in human cancers. However, the roles of m6A binding protein… read more here.
Keywords: cancer progression; methyladenosine m6a; igf2bp2; gastric cancer ... See more keywords
The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers
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DOI: 10.2147/ott.s283417
Abstract: Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene(FTO), previously recognized to be related with obesity and diabetes, was gradually discovered to be dysregulated in multiple cancers and plays an oncogenic or tumor-suppressive role. However,… read more here.
Keywords: role; fat mass; obesity; methyladenosine m6a ... See more keywords
Corrigendum: Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.640806
Abstract: [This corrects the article DOI: 10.3389/fcell.2020.00782.]. read more here.
Keywords: methyladenosine m6a; corrigendum roles; m6a stem; roles methyladenosine ... See more keywords
Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
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DOI: 10.3389/fcell.2022.946219
Abstract: Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the… read more here.
Keywords: m6a modification; role; methyladenosine m6a; regulatory role ... See more keywords
Prognostic N6-methyladenosine (m6A)-related lncRNA patterns to aid therapy in pancreatic ductal adenocarcinoma
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DOI: 10.3389/fgene.2022.866340
Abstract: Background: Mounting research studies have suggested the indispensable roles of N6-methyladenosine (m6A) RNA modification in carcinogenesis. Nevertheless, it was little known about the potential function of m6A-related lncRNAs in sample clustering, underlying mechanism, and anticancer… read more here.
Keywords: related lncrna; m6a related; methyladenosine m6a; m6a ... See more keywords
Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.955222
Abstract: N6-methyladenosine (m6A) is the most abundant post-transcription modification, widely occurring in eukaryotic mRNA and non-coding RNA. m6A modification is highly enriched in the mammalian brain and is associated with neurological diseases like Alzheimer’s disease (AD)… read more here.
Keywords: m6a modification; methyladenosine m6a; m6a; stroke ... See more keywords
The Role of N6-Methyladenosine (m6A) Methylation Modifications in Hematological Malignancies
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DOI: 10.3390/cancers14020332
Abstract: Simple Summary Recently, despite the common application of various novel therapies (e.g., immunotherapy and stem cell transplantation) in hematologic tumors, hematologic malignancies remain suboptimal and have a worse prognosis due to the lack of donors… read more here.
Keywords: methylation; hematologic malignancies; role; m6a methylation ... See more keywords