Assessment of the cytotoxic impact of cyanotoxin beta-N-methylamino-L-alanine on a fish immune cell line.
Sign Up to like & getrecommendations! Published in 2019 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2019.05.012
Abstract: Beta-N-methylamino-L-alanine (BMAA) is a non-proteinogenic amino acid produced by several cyanobacteria species. It is considered to be a potent neurotoxin. Although its neurotoxic effects are well studied, other negative effects of BMAA have not yet… read more here.
Keywords: immune cell; cell line; beta methylamino; fish immune ... See more keywords
A tRNA t6A modification system contributes to the sensitivity towards the toxin β-N-methylamino-L-alanine (BMAA) in the cyanobacterium Anabaena sp. PCC 7120.
Sign Up to like & getrecommendations! Published in 2022 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2022.106121
Abstract: Cyanobacteria are oxygen-evolving photosynthetic autotrophs essential for nutrient cycling in the environment. They possess multiple control mechanisms for their cellular activities in order to adapt to the environment. While protein translation is essential for cell… read more here.
Keywords: alanine bmaa; cyanobacterium anabaena; bmaa; t6a ... See more keywords
L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.01.007
Abstract: Background: L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) is a non‐proteinic amino acid, that is neurotoxic in vitro and in animals, and is implicated in the causation of amyotrophic lateral sclerosis and parkinsonism‐dementia complex (ALS‐PDC) on Guam. Given that natural… read more here.
Keywords: alanine bmaa; alkylating agent; bgr methylamino; bmaa ... See more keywords
Behavior and gene expression in the brain of adult self-fertilizing mangrove rivulus fish (Kryptolebias marmoratus) after early life exposure to the neurotoxin β-N-methylamino-L-alanine (BMAA).
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.04.007
Abstract: β-N-methylamino-L-alanine (BMAA), a neurotoxin naturally produced by cyanobacteria, diatoms and dinoflagellates, constitutes a serious environmental and health threat especially during acute blooms, which are becoming more frequent. This neurotoxin is implicated in several neurodegenerative diseases… read more here.
Keywords: alanine bmaa; expression; neurotoxin; bmaa ... See more keywords
Chiral analysis of β-methylamino alanine (BMAA) enantiomers after (+)-1-(9-fluorenyl)-ethyl chloroformate (FLEC) derivatization and LC-MS/MS
Sign Up to like & getrecommendations! Published in 2019 at "Analytical Methods"
DOI: 10.1039/c8ay02287a
Abstract: A developed method for chiral analysis of neurotoxin β-methylamino alanine (BMAA) allowed detection of d-BMAA in cycad seed samples. read more here.
Keywords: methylamino alanine; alanine bmaa; chiral analysis; bmaa ... See more keywords
Improved quantification of the cyanobacteria metabolite, β-methylamino-l-alanine (BMAA) using HPLC-MS/MS detection of its dansyl chloride derivative referenced to a15N-labeled internal standard
Sign Up to like & getrecommendations! Published in 2019 at "Analytical Methods"
DOI: 10.1039/c9ay00284g
Abstract: Historic disagreement regarding the prevalence and abundance of BMAA may be due in part to false-negative results arising from deuterated internal standards and the derivatization conditions used in prior studies. read more here.
Keywords: methylamino alanine; quantification cyanobacteria; improved quantification; metabolite methylamino ... See more keywords
Putative biosynthesis mechanism of the neurotoxin β-N-methylamino-L-alanine in marine diatoms based on a transcriptomics approach.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hazardous materials"
DOI: 10.2139/ssrn.4157129
Abstract: The neurotoxin β-N-methylamino-L-alanine (BMAA) has been presumed as an environmental cause of human neurodegenerative disorders, such as Alzheimer's disease. Marine diatoms Thalassiosira minima are demonstrated here to produce BMAA-containing proteins in axenic culture while the… read more here.
Keywords: biosynthesis; neurotoxin methylamino; marine diatoms; methylamino alanine ... See more keywords
Effect of Microcystin-LR, Nodularin, Anatoxin-a, β-N-Methylamino-L-Alanine and Domoic Acid on Antioxidant Properties of Glutathione
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12020227
Abstract: Cyanobacteria produce a range of toxic secondary metabolites that affect many processes in human, animal and also plant cells. In recent years, some efforts have concentrated on deepening the understanding of their effect on living… read more here.
Keywords: effect; methylamino alanine; anatoxin methylamino; antioxidant properties ... See more keywords
Transfer of the Neurotoxin β-N-methylamino-l-alanine (BMAA) in the Agro–Aqua Cycle
Sign Up to like & getrecommendations! Published in 2020 at "Marine Drugs"
DOI: 10.3390/md18050244
Abstract: The neurotoxic non-protein amino acid β-N-methylamino-l-alanine (BMAA) is connected to the development of neurodegenerative diseases. BMAA has been shown to accumulate in aquatic ecosystems, and filter-feeding molluscs seem particularly susceptible to BMAA accumulation. The blue… read more here.
Keywords: aqua cycle; agro aqua; alanine bmaa; bmaa ... See more keywords
Occurrence of β-N-methylamino-l-alanine (BMAA) and Isomers in Aquatic Environments and Aquatic Food Sources for Humans
Sign Up to like & getrecommendations! Published in 2018 at "Toxins"
DOI: 10.3390/toxins10020083
Abstract: The neurotoxin β-N-methylamino-l-alanine (BMAA), a non-protein amino acid produced by terrestrial and aquatic cyanobacteria and by micro-algae, has been suggested to play a role as an environmental factor in the neurodegenerative disease Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia… read more here.
Keywords: bmaa isomers; bmaa; alanine bmaa; aquatic environments ... See more keywords
Matrix Effect of Diverse Biological Samples Extracted with Different Extraction Ratios on the Detection of β-N-Methylamino-L-Alanine by Two Common LC-MS/MS Analysis Methods
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14060387
Abstract: Neurotoxin β-N-methylamino-L-alanine (BMAA) is hypothesized as an important pathogenic factor for neurodegenerative diseases such as amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS-PDC). Comparative study on the accuracy of BMAA analyzed by the regular LC-MS/MS methods is still… read more here.
Keywords: extraction ratios; bmaa; methylamino alanine; analysis ... See more keywords