Total Synthesis of the Highly N-Methylated Acetylene-Containing Anticancer Peptide Jahanyne.
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DOI: 10.1021/acs.orglett.7b03925
Abstract: The first total synthesis of the highly N-methylated acetylene-containing lipopeptide jahanyne, an apoptosis-inducing natural product from marine cyanobacteria, is reported. A late-stage solution-phase coupling enabled introduction of the C-terminal ketone pyrrolidine moiety. A modified Fmoc… read more here.
Keywords: jahanyne; highly methylated; methylated acetylene; total synthesis ... See more keywords