Walking the DNA Methylation Tightrope: The Involvement of Intrinsically Disordered Regions of Transcription Factors
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1144
Abstract: Most 5-methylcytosine-binding domain proteins (such as MeCP2 and MBD1-6) contain a highly conserved 70 amino acid methyl-CpG-binding domain (MBD). The founding member of vertebrate MBD proteins, MBD2, is associated with the Nucleosome Remodeling Deacetylase complex… read more here.
Keywords: mbd2mbd idr; walking dna; dna; idr ... See more keywords
Cys2His2 zinc finger methyl-CpG binding proteins: Getting a handle on methylated DNA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.012
Abstract: DNA methylation is an essential epigenetic modification involved in the maintenance of genomic stability, preservation of cellular identity, and regulation of the transcriptional landscape needed to maintain cellular function. In an increasing number of disease… read more here.
Keywords: binding proteins; dna; zinc finger; methyl cpg ... See more keywords
Evaluation of un-methylated DNA enrichment in sequencing of African swine fever virus complete genome.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2020.113959
Abstract: African swine fever is a febrile hemorrhagic fever disease that is caused by the African swine fever virus (ASFV) and is lethal for domestic pigs and wild boar. ASFV also infects soft ticks of the… read more here.
Keywords: swine fever; african swine; fever; dna enrichment ... See more keywords
Immuno-cytometric detection of circulating cell free methylated DNA, post-translationally modified histones and micro RNAs using semi-conducting nanocrystals.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2020.121516
Abstract: The diagnostic potential of cell free epigenomic signatures is largely driven by the fact that manifold quantities of methylated DNA, post-translationally modified histones and micro RNAs are released into systemic circulation in various non-communicable diseases.… read more here.
Keywords: micro rnas; methylated dna; detection; cell free ... See more keywords
Methylated DNA markers for plasma detection of ovarian cancer: Discovery, validation, and clinical feasibility.
Sign Up to like & getrecommendations! Published in 2022 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2022.03.018
Abstract: OBJECTIVE Aberrant DNA methylation is an early event in carcinogenesis which could be leveraged to detect ovarian cancer (OC) in plasma. METHODS DNA from frozen OC tissues, benign fallopian tube epithelium (FTE), and buffy coats… read more here.
Keywords: methylated dna; dna markers; ovarian cancer; validation ... See more keywords
A 5′-Flanking C/G Pair at the Core Region Enhances the Recognition and Binding of Kaiso to Methylated DNA
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01294
Abstract: Methyl CpG binding proteins (MBPs) are transcription factors that recognize the methylated CpG sites in DNA and mediate the DNA methylation signal into various downstream cellular processes. The C2H2 zinc finger (ZF) protein, Kaiso, also… read more here.
Keywords: recognition; pair; kaiso; methylated dna ... See more keywords
Identifying Transcription Factors That Prefer Binding to Methylated DNA Using Reduced G-Gap Dipeptide Composition
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03696
Abstract: Transcription factors (TFs) play an important role in gene expression and regulation of 3D genome conformation. TFs have ability to bind to specific DNA fragments called enhancers and promoters. Some TFs bind to promoter DNA… read more here.
Keywords: dna; transcription; methylated dna; tfs ... See more keywords
Rett mutations attenuate phase separation of MeCP2
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-0172-0
Abstract: Dear Editor, Methyl-CpG-binding protein 2 (MeCP2) is a ubiquitously expressed nuclear protein originally identified as a methylated DNA binding protein, which is particularly abundant in mature neurons. Deficiency or excess of MeCP2 causes severe neurological… read more here.
Keywords: phase separation; dna; mecp2; fig ... See more keywords
Identification of DNA methylated regions by using methylated DNA immunoprecipitation sequencing in Brassica rapa
Sign Up to like & getrecommendations! Published in 2018 at "Crop and Pasture Science"
DOI: 10.1071/cp17394
Abstract: Abstract. DNA methylation is an epigenetic gene regulatory mechanism that plays an essential role in gene expression, transposon silencing, genome imprinting and plant development. We investigated the influence of DNA methylation on gene expression in… read more here.
Keywords: methylation; brassica rapa; methylated dna; inbred lines ... See more keywords
Finding de novo methylated DNA motifs
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz079
Abstract: Motivation Increasing evidence has shown that nucleotide modifications such as methylation and hydroxymethylation on cytosine would greatly impact the binding of transcription factors (TFs). However, there is a lack of motif finding algorithms with the… read more here.
Keywords: dna; novo methylated; finding novo; methylated motifs ... See more keywords
Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw2880
Abstract: The discovery of AD epigenetic signatures lays a molecular basis for new methods to detect early AD using patient blood cells. Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the most common untreatable form of… read more here.
Keywords: epigenetic signatures; alzheimer disease; signatures methylated; cytosine ... See more keywords