Mono-methylated histones control PARP-1 in chromatin and transcription
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DOI: 10.1101/2023.11.22.568326
Abstract: PARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks,… read more here.
Keywords: methylated histones; parp; heat; heat shock ... See more keywords
Abstract 4766: Hypoxia increases the methylated histones to prevent histone clipping during Raf-induced senescence
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4766
Abstract: Hypoxia increases methylated histones by inhibiting O2- and α-ketoglutarate-dependent histone lysine demethylases (KDMs). This study is the first to demonstrate how the hypoxic increment of methylated histones cross-talks with other epigenetic changes, such as histone… read more here.
Keywords: methylated histones; histone; hypoxia; senescence ... See more keywords