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   Articles with "methylation" as a keyword



Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer

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recommendations! Published in 2022 at "JAMA Oncology"

DOI: 10.1001/jamaoncol.2022.3846

Abstract: Key Points Question Is mosaic BRCA1 promoter methylation in normal tissue associated with the risk of incident high-grade serous ovarian cancer (HGSOC) and triple-negative breast cancer (TNBC)? Findings In this nested case-control study including 637… read more here.

Keywords: brca1; methylation; high grade; risk incident ... See more keywords

Urinary DNA Methylation Test for Bladder Cancer Diagnosis.

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recommendations! Published in 2025 at "JAMA oncology"

DOI: 10.1001/jamaoncol.2024.6160

Abstract: Importance An accurate noninvasive biomarker test is needed for the early diagnosis of bladder cancer. Objective To evaluate the performance of a urinary DNA methylation test (PENK methylation) and compare its diagnostic accuracy with that… read more here.

Keywords: cytology; test; methylation; bladder cancer ... See more keywords

The genome of the Cauliflower mosaic virus, a plant pararetrovirus, is highly methylated in the nucleus

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recommendations! Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13852

Abstract: Cytosine methylation is an important defense against invasive DNAs. Here, cytosine methylation profiles of a plant pararetrovirus, Cauliflower mosaic virus (CaMV), were investigated. Nuclear CaMV DNA is highly methylated throughout the genome including at transcription… read more here.

Keywords: methylation; highly methylated; mosaic virus; cauliflower mosaic ... See more keywords

Methylation‐associated miR‐193b silencing activates master drivers of aggressive prostate cancer

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12536

Abstract: Epigenetic silencing of miRNA is a primary mechanism of aberrant miRNA expression in cancer, and hypermethylation of miRNA promoters has been reported to contribute to prostate cancer initiation and progression. Recent data have shown that… read more here.

Keywords: methylation; prostate cancer; cancer; mir 193b ... See more keywords

Individual and joint performance of DNA methylation profiles, genetic risk score and environmental risk scores for predicting breast cancer risk

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12594

Abstract: DNA methylation patterns in the blood, genetic risk scores (GRSs), and environmental risk factors can potentially improve breast cancer (BC) risk prediction. We assessed the individual and joint predictive performance of methylation, GRS, and environmental… read more here.

Keywords: methylation; risk; environmental risk; performance ... See more keywords
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The DNA methylation landscape of hematological malignancies: an update

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recommendations! Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12744

Abstract: The rapid advances in high‐throughput sequencing technologies have made it more evident that epigenetic modifications orchestrate a plethora of complex biological processes. During the last decade, we have gained significant knowledge about a wide range… read more here.

Keywords: methylation; landscape hematological; methylation landscape; hematological malignancies ... See more keywords
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Identification and validation of novel DNA methylation markers for early diagnosis of lung adenocarcinoma

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recommendations! Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12767

Abstract: Lung cancer has the highest mortality of all cancers worldwide. Epigenetic alterations have emerged as potential biomarkers for early diagnosis of various cancer tissue types. To identify methylation markers for early diagnosis of lung adenocarcinoma,… read more here.

Keywords: lung adenocarcinoma; methylation; dna methylation; methylation markers ... See more keywords
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Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early‐stage NSCLC patients

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recommendations! Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12785

Abstract: Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non‐small‐cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early‐stage… read more here.

Keywords: methylation; nsclc patients; early stage; overall survival ... See more keywords
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Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors

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recommendations! Published in 2021 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12909

Abstract: Testicular germ cell tumors (TGCTs) are the most common cancers in men aged 15–39 years and are divided into two major groups, seminomas and nonseminomas. Novel treatment options are required for these patients, to limit… read more here.

Keywords: methylation; testicular germ; promoter methylation; germ cell ... See more keywords

Dynamic methylation and expression of alternative promoters for oestrogen receptor alpha in cell line models of fulvestrant resistance

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13713

Abstract: Oestrogen receptor alpha (ER; gene symbol ESR1) is the most important prognostic and treatment‐predictive biomarker in breast cancer. Drugs targeting oestrogen and ER for endocrine therapy of breast cancer include aromatase inhibitors, the selective ER… read more here.

Keywords: methylation; resistance; cell line; oestrogen receptor ... See more keywords

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies.

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recommendations! Published in 2025 at "Molecular oncology"

DOI: 10.1002/1878-0261.70159

Abstract: Pleural mesothelioma (PM) is a rare and aggressive cancer that often requires multiple diagnostic procedures before a definitive diagnosis can be made. To improve diagnostic accuracy, we developed a DNA methylation-based biomarker assay capable of… read more here.

Keywords: methylation; pleural pathologies; pleural mesothelioma; pleura pleural ... See more keywords