In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neuropathologica"
DOI: 10.1007/s00401-025-02939-7
Abstract: DNA methylation-based classification using the Heidelberg Classifier is a state-of-the-art data-driven method for molecular diagnosis of central nervous system (CNS) tumors. However, many pediatric low-grade glioma (pLGG) samples fail to yield a confident methylation-based classification,… read more here.
Keywords: classification; methylation based; methylation; purification ... See more keywords
Validation of a methylation-based signature for subventricular zone involvement in glioblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-024-04570-0
Abstract: Glioblastomas (GBM) with subventricular zone (SVZ) contact have previously been associated with a specific epigenetic fingerprint. We aim to validate a reported bulk methylation signature to determine SVZ contact. Methylation array analysis was performed on… read more here.
Keywords: methylation based; methylation; signature; subventricular zone ... See more keywords
DNA Methylation based prognostic subtypes of chordoma tumors in tissue and plasma.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab235
Abstract: BACKGROUND Chordomas are rare malignant bone cancers of the skull-base and spine. Patient survival is variable and not reliably predicted using clinical factors or molecular features. This study identifies prognostic epigenetic chordoma subtypes that are… read more here.
Keywords: methylation; dna methylation; plasma methylomes; methylation based ... See more keywords
DNA methylation‐based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification
Sign Up to like & getrecommendations! Published in 2023 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12894
Abstract: Glioneuronal tumours (GNTs) are poorly distinguished by their histology and lack robust diagnostic indicators. Previously, we showed that common GNTs comprise two molecularly distinct groups, correlating poorly with histology. To refine diagnosis, we constructed a… read more here.
Keywords: radiology; glioneuronal tumours; molecular stratification; methylation based ... See more keywords
Abstract 979: Development of a methylation-based classifier to identify pancreatic adenocarcinoma subtype
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-979
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) demonstrates variable prognosis and response to first-line FOLFIRINOX therapy depending on molecular subtype; patients with classical tumors showed a greater response compared to basal-like tumors. Identifying molecular subtype may inform… read more here.
Keywords: methylation; methylation based; based classifier; adenocarcinoma ... See more keywords
Abstract 2618: Methylation-based epigenetic “switches” in group 3/4 medulloblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2618
Abstract: Medulloblastoma (MB) is the most common primary brain tumor in children, with group 3 and group 4 (G3/4) being the most aggressive. Methylation studies have identified eight distinct subgroups within G3/4 MB, with observed differences… read more here.
Keywords: methylation based; methylation; based epigenetic; group ... See more keywords
Abstract B012: M-PACT: Methylation-based predictive algorithm for CNS tumor liquid biopsies
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.liqbiop24-b012
Abstract: Background: DNA methylation-based classification has been transformative in the molecular diagnostics of pediatric central nervous system (CNS) tumors. Current diagnostic pipelines integrate histopathology and molecular tools in accordance with the WHO classification of CNS tumors… read more here.
Keywords: oncology; methylation based; methylation; liquid ... See more keywords
Methylation-Based Biological Age and Hypertension Prevalence and Incidence
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DOI: 10.1161/hypertensionaha.122.20796
Abstract: Background: Hypertension is common in older individuals and is a major risk factor for cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of biological age that capture age-related physiological change, disease… read more here.
Keywords: hypertension; methylation based; age; biological age ... See more keywords
Rapid DNA-methylation based classification of hematological malignancies
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DOI: 10.1182/blood-2025-119
Abstract: Accurate molecular classification of hematological malignancies is essential for treatment and prognosis. Current diagnostic workflows include a range of tools, including flow-cytometry, karyotyping, NGS, RNA-sequencing and more. These can be time-consuming and expensive, leading to… read more here.
Keywords: classification; diagnosis; methylation based; methylation ... See more keywords
A DNA methylation-based classifier for accurate molecular diagnosis of bone sarcomas.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.11034
Abstract: 11034Background: Bone sarcomas present a unique diagnostic challenge because of the considerable morphologic overlap between different entities. The choice of optimal treatment, however, is dependent upon accurate diagnosis. Genome-wide DNA methylation profiling has emerged as… read more here.
Keywords: methylation; diagnosis; methylation based; based classifier ... See more keywords
Association between epigenomic biomarkers and baseline clinical characteristics in patients with mCRPC treated with rucaparib in TRITON2.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.5086
Abstract: 5086 Background: TRITON2 is a phase 2 study evaluating rucaparib in 277 patients with metastatic castration resistant prostate cancer (mCRPC). PSA has been used to predict radiographic progression free survival (rPFS), overall survival (OS) and… read more here.
Keywords: patients mcrpc; methylation based; methylation; triton2 ... See more keywords