DNA Methylation based prognostic subtypes of chordoma tumors in tissue and plasma.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab235
Abstract: BACKGROUND Chordomas are rare malignant bone cancers of the skull-base and spine. Patient survival is variable and not reliably predicted using clinical factors or molecular features. This study identifies prognostic epigenetic chordoma subtypes that are… read more here.
Keywords: methylation; dna methylation; plasma methylomes; methylation based ... See more keywords
DNA methylationâbased classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification
Sign Up to like & getrecommendations! Published in 2023 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12894
Abstract: Glioneuronal tumours (GNTs) are poorly distinguished by their histology and lack robust diagnostic indicators. Previously, we showed that common GNTs comprise two molecularly distinct groups, correlating poorly with histology. To refine diagnosis, we constructed a… read more here.
Keywords: radiology; glioneuronal tumours; molecular stratification; methylation based ... See more keywords
Abstract 979: Development of a methylation-based classifier to identify pancreatic adenocarcinoma subtype
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-979
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) demonstrates variable prognosis and response to first-line FOLFIRINOX therapy depending on molecular subtype; patients with classical tumors showed a greater response compared to basal-like tumors. Identifying molecular subtype may inform… read more here.
Keywords: methylation; methylation based; based classifier; adenocarcinoma ... See more keywords
Methylation-Based Biological Age and Hypertension Prevalence and Incidence
Sign Up to like & getrecommendations! Published in 2023 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.20796
Abstract: Background: Hypertension is common in older individuals and is a major risk factor for cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of biological age that capture age-related physiological change, disease… read more here.
Keywords: hypertension; methylation based; age; biological age ... See more keywords
A DNA methylation-based classifier for accurate molecular diagnosis of bone sarcomas.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.11034
Abstract: 11034Background: Bone sarcomas present a unique diagnostic challenge because of the considerable morphologic overlap between different entities. The choice of optimal treatment, however, is dependent upon accurate diagnosis. Genome-wide DNA methylation profiling has emerged as… read more here.
Keywords: methylation; diagnosis; methylation based; based classifier ... See more keywords
Predicting cancer origins with a DNA methylation-based deep neural network model
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0226461
Abstract: Cancer origin determination combined with site-specific treatment of metastatic cancer patients is critical to improve patient outcomes. Existing pathology and gene expression-based techniques often have limited performance. In this study, we developed a deep neural… read more here.
Keywords: methylation based; cancer origins; pathology; cancer ... See more keywords
Establishment of Novel DNA Methylation-Based Prostate Cancer Subtypes and a Risk-Predicting Eight-Gene Signature
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.639615
Abstract: Prostate cancer (PCa) is the most common malignant tumor affecting males worldwide. The substantial heterogeneity in PCa presents a major challenge with respect to molecular analyses, patient stratification, and treatment. Least absolute shrinkage and selection… read more here.
Keywords: methylation; risk; methylation based; prostate cancer ... See more keywords