Applying Promiscuous RiPP Enzymes to Peptide Backbone N-Methylation Chemistry.
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DOI: 10.1021/acschembio.2c00293
Abstract: The methylation of peptide backbone amides is a hallmark of bioactive natural products, and it also greatly modifies the pharmacology of synthetic peptides. Usually, bioactive N-methylated peptides are cyclic. However, there is very limited knowledge… read more here.
Keywords: methylation; methylation chemistry; methylated peptides; chemistry ... See more keywords