7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.
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DOI: 10.1021/acs.jmedchem.9b00770
Abstract: TGR5 agonists are potential therapeutics for a variety of conditions including type 2 diabetes, obesity, and inflammatory bowel disease. After screening a library of chenodeoxycholic acid (CDCA) derivatives, it was determined that a range of… read more here.
Keywords: potency; increase; chenodeoxycholic acid; methylation chenodeoxycholic ... See more keywords