Aberrant DNA methylation defines isoform usage in cancer, with functional implications
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DOI: 10.1371/journal.pcbi.1007095
Abstract: Alternative transcript isoforms are common in tumors and act as potential drivers of cancer. Mechanisms determining altered isoform expression include somatic mutations in splice regulatory sites or altered splicing factors. However, since DNA methylation is… read more here.
Keywords: methylation; isoform; aberrant dna; cancer ... See more keywords