X-chromosome inactivation patterns in females with Fabry disease examined by both ultra-deep RNA sequencing and methylation-dependent assay
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-021-02099-4
Abstract: Fabry disease is an X-linked inherited lysosomal storage disorder caused by mutations in the gene encoding α-galactosidase A. Males are usually severely affected, while females have a wide range of disease severity. This variability has… read more here.
Keywords: methylation dependent; chromosome inactivation; fabry disease; disease ... See more keywords
Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale horizons"
DOI: 10.1039/d0nh00258e
Abstract: Extracellular vesicles (EV) play a major role in intercellular communication by transmitting cellular materials (e.g. protein, RNA) among distant cells. Recent evidence suggests that they could also contribute to carrying DNA which could inform on… read more here.
Keywords: evdna; dna; dependent gold; cancer ... See more keywords
Set1 regulates telomere function via H3K4 methylation–dependent and -independent pathways and calibrates the abundance of telomere maintenance factors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-06-0213
Abstract: Set1 is an H3K4 methyltransferase which comprises the catalytic subunit of the COMPASS complex and has been implicated in transcription, DNA repair, cell cycle control, and numerous other genomic functions. Set1 also promotes proper telomere… read more here.
Keywords: set1; methylation dependent; h3k4 methylation; telomere maintenance ... See more keywords