In vitro evaluation of the effect of C-4 substitution on methylation of 7,8-dihydroxycoumarin: metabolic profile and catalytic kinetics
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DOI: 10.1098/rsos.171271
Abstract: Daphnetin (7,8-dihydroxycoumarin (7,8-DHC)) and its C-4 derivatives have multiple pharmacological activities, but the poor metabolic stability of these catechols has severely restricted their application in the clinic. Methylation plays important roles in catechol elimination, although… read more here.
Keywords: methylation; methylation dihydroxycoumarin; vitro evaluation; evaluation effect ... See more keywords