Interplay between the miRNome and the epigenetic machinery: Implications in health and disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25819
Abstract: Epigenetics refers to functionally relevant genomic changes that do not involve changes in the basic nucleotide sequence. Majorly, these are of two types: DNA methylation and histone modifications. Small RNA molecules called miRNAs are often… read more here.
Keywords: machinery; mir; health disease; methylation histone ... See more keywords
DNA methylation and histone variants in aging and cancer.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.06.002
Abstract: Aging-related diseases such as cancer can be traced to the accumulation of molecular disorder including increased DNA mutations and epigenetic drift. We provide a comprehensive review of recent results in mice and humans on modifications… read more here.
Keywords: variants aging; histone variants; cancer; methylation histone ... See more keywords
Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.01.075
Abstract: SUMMARY Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA… read more here.
Keywords: cell; methylation histone; dna methylation; memory ... See more keywords
Moving pharmacoepigenetics tools for depression toward clinical use.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2019.02.009
Abstract: BACKGROUND Major depressive disorder (MDD) is a leading cause of disability worldwide, and over half of patients do not achieve symptom remission following an initial antidepressant course. Despite evidence implicating a strong genetic basis for… read more here.
Keywords: depression; histone modifications; response; treatment ... See more keywords
Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.05.013
Abstract: Cryo-EM structures of Dot1L in complex with a ubiquitinated nucleosome provide the long-sought-after molecular mechanism of Dot1L-mediated methylation of lysine 79 in histone H3 and explain crosstalk with histone H2B ubiquitination. read more here.
Keywords: histone h3k79; ubiquitinated nucleosome; methylation histone; histone ... See more keywords
Noncoding RNAs involved in DNA Methylation and Histone methylation, and acetylation in Diabetic Vascular Complications.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105520
Abstract: Diabetes is a metabolic disorder and its incidence is still increasing. Diabetic vascular complications cause major diabetic mobility and include accelerated atherosclerosis, nephropathy, retinopathy, and neuropathy. Hyperglycemia contributes to the pathogenesis of diabetic vascular complications… read more here.
Keywords: methylation; diabetic vascular; histone methylation; vascular complications ... See more keywords
Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222212170
Abstract: The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on… read more here.
Keywords: histone modifications; systematic review; rheumatoid arthritis; methylation histone ... See more keywords