Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML.
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DOI: 10.1182/bloodadvances.2020001922
Abstract: Understanding mechanisms of cooperation between oncogenes is critical for the development of novel therapies and rational combinations. Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2APTD) are known to depend on… read more here.
Keywords: methylation; patterns h3k79; methylation influence; interaction ... See more keywords