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   Articles with "methylation levels" as a keyword



Aberrant methylation status of SPG20 promoter in hepatocellular carcinoma: A potential tumor metastasis biomarker.

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recommendations! Published in 2019 at "Cancer genetics"

DOI: 10.1016/j.cancergen.2019.04.003

Abstract: PURPOSE The aim of this study is to analyze the methylation levels of SPG20 promotor region and explore the association between the methylation levels and clinical features in hepatocellular carcinoma (HCC). MATERIALS AND METHODS We… read more here.

Keywords: hepatocellular carcinoma; methylation levels; hcc; metastasis ... See more keywords

Investigation of GHSR methylation levels in thymomas from patients with Myasthenia Gravis.

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recommendations! Published in 2020 at "Gene"

DOI: 10.1016/j.gene.2020.144774

Abstract: BACKGROUND Hypermethylation of the growth hormone secretagogue receptor gene (GHSR) is increasingly observed in human cancers, suggesting that it could represent a pan-cancer biomarker of clinical interest. However, little is still known concerning GHSR methylation… read more here.

Keywords: patients myasthenia; thymomas patients; ghsr methylation; myasthenia gravis ... See more keywords
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Hypomethylation of C1q/tumor necrosis factor-related protein-1 promoter region in whole blood and risks for coronary artery aneurysms in Kawasaki disease.

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recommendations! Published in 2020 at "International journal of cardiology"

DOI: 10.1016/j.ijcard.2020.02.002

Abstract: BACKGROUND Kawasaki disease (KD) is characterized as a self-limited systemic vasculitis. C1q/tumor necrosis factor-related protein-1 (CTRP1) had been associated with the occurrence of vasculitis in KD. Methylation at the promoter region of certain genes was… read more here.

Keywords: promoter region; methylation; group; methylation levels ... See more keywords

Dietary fish and ω-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels.

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recommendations! Published in 2020 at "Nutrition"

DOI: 10.1016/j.nut.2020.110951

Abstract: OBJECTIVES A diet rich in fish and ω-3 polyunsaturated fatty acids (PUFAs) has been thought to reduce the risk for cardiovascular disease (CVD). The beneficial effects of fish oil and ω-3 PUFA on CVD can… read more here.

Keywords: dna; dietary fish; abca1 dna; dna methylation ... See more keywords

Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia

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recommendations! Published in 2019 at "Journal of Human Genetics"

DOI: 10.1038/s10038-019-0672-7

Abstract: Both betaine homocysteine methyltransferase (BHMT) and cystathionine β-synthase (CBS) are major enzymes in the metabolism of plasma homocysteine (Hcy). Abnormal methylation levels of BHMT and CBS are positively associated with Hcy levels. The present study… read more here.

Keywords: folic acid; methylation; acid therapy; bhmt cbs ... See more keywords

Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-69248-9

Abstract: Early diagnosis of dementia including Alzheimer’s disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene,… read more here.

Keywords: methylation; alzheimer disease; pathology; blood ... See more keywords

Interaction between gender and age on the methylation levels of KLF14 promoter

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-01536-8

Abstract: This study investigated the relationship between age, sex, and methylation levels of the Krüppel-like factor 14 (KLF14) promoter. Utilizing data from the Taiwan Biobank (TWB), established in 2005, we analyzed a cohort of 1,141 participants.… read more here.

Keywords: age; methylation; methylation levels; levels klf14 ... See more keywords

Methylation of LINE-1 and Alu repetitive sequence in keloid

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-17646-2

Abstract: Keloid is a trauma-induced fibroproliferative condition characterized by excessive extracellular matrix (ECM) deposition and aberrant keloid fibroblast activation, leading to physical, psychological, functional, and cosmetic impairments. This study investigates DNA methylation alterations at Long Interspersed… read more here.

Keywords: methylation; methylation levels; line alu; line ... See more keywords

DNA methylation analysis of multiple genes in thymic epithelial tumors.

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recommendations! Published in 2024 at "Epigenomics"

DOI: 10.1080/17501911.2024.2419362

Abstract: Aim: To investigate DNA methylation levels of a panel of genes in thymic epithelial tumors (TETs).Materials & methods: We selected 15 genes among the most promising epigenetic biomarkers of TETs and evaluated their methylation levels… read more here.

Keywords: methylation; genes thymic; epithelial tumors; methylation levels ... See more keywords

A comprehensive comparison of residue-level methylation levels with the regression-based gene-level methylation estimations by ReGear

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recommendations! Published in 2021 at "Briefings in bioinformatics"

DOI: 10.1093/bib/bbaa253

Abstract: MOTIVATION DNA methylation is a biological process impacting the gene functions without changing the underlying DNA sequence. The DNA methylation machinery usually attaches methyl groups to some specific cytosine residues, which modify the chromatin architectures.… read more here.

Keywords: gene level; methylation; level methylation; gene ... See more keywords

MAEL promoter hypermethylation is associated with de-repression of LINE-1 in human hypospermatogenesis

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recommendations! Published in 2017 at "Human Reproduction"

DOI: 10.1093/humrep/dex329

Abstract: STUDY QUESTION Does the hypermethylation of the maelstrom spermatogenic transposon silencer (MAEL) promoter and subsequent de-repression of transposable elements represent one of the causes of spermatogenic failure in infertile men? SUMMARY ANSWER Experimental hypermethylation of… read more here.

Keywords: methylation; mael; mael promoter; hypermethylation ... See more keywords