Aberrant methylation status of SPG20 promoter in hepatocellular carcinoma: A potential tumor metastasis biomarker.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.04.003
Abstract: PURPOSE The aim of this study is to analyze the methylation levels of SPG20 promotor region and explore the association between the methylation levels and clinical features in hepatocellular carcinoma (HCC). MATERIALS AND METHODS We… read more here.
Keywords: hepatocellular carcinoma; methylation levels; hcc; metastasis ... See more keywords
Investigation of GHSR methylation levels in thymomas from patients with Myasthenia Gravis.
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DOI: 10.1016/j.gene.2020.144774
Abstract: BACKGROUND Hypermethylation of the growth hormone secretagogue receptor gene (GHSR) is increasingly observed in human cancers, suggesting that it could represent a pan-cancer biomarker of clinical interest. However, little is still known concerning GHSR methylation… read more here.
Keywords: patients myasthenia; thymomas patients; ghsr methylation; myasthenia gravis ... See more keywords
Hypomethylation of C1q/tumor necrosis factor-related protein-1 promoter region in whole blood and risks for coronary artery aneurysms in Kawasaki disease.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2020.02.002
Abstract: BACKGROUND Kawasaki disease (KD) is characterized as a self-limited systemic vasculitis. C1q/tumor necrosis factor-related protein-1 (CTRP1) had been associated with the occurrence of vasculitis in KD. Methylation at the promoter region of certain genes was… read more here.
Keywords: promoter region; methylation; group; methylation levels ... See more keywords
Dietary fish and ω-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels.
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DOI: 10.1016/j.nut.2020.110951
Abstract: OBJECTIVES A diet rich in fish and ω-3 polyunsaturated fatty acids (PUFAs) has been thought to reduce the risk for cardiovascular disease (CVD). The beneficial effects of fish oil and ω-3 PUFA on CVD can… read more here.
Keywords: dna; dietary fish; abca1 dna; dna methylation ... See more keywords
Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia
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DOI: 10.1038/s10038-019-0672-7
Abstract: Both betaine homocysteine methyltransferase (BHMT) and cystathionine β-synthase (CBS) are major enzymes in the metabolism of plasma homocysteine (Hcy). Abnormal methylation levels of BHMT and CBS are positively associated with Hcy levels. The present study… read more here.
Keywords: folic acid; methylation; acid therapy; bhmt cbs ... See more keywords
Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease
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DOI: 10.1038/s41598-020-69248-9
Abstract: Early diagnosis of dementia including Alzheimer’s disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene,… read more here.
Keywords: methylation; alzheimer disease; pathology; blood ... See more keywords
A comprehensive comparison of residue-level methylation levels with the regression-based gene-level methylation estimations by ReGear
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DOI: 10.1093/bib/bbaa253
Abstract: MOTIVATION DNA methylation is a biological process impacting the gene functions without changing the underlying DNA sequence. The DNA methylation machinery usually attaches methyl groups to some specific cytosine residues, which modify the chromatin architectures.… read more here.
Keywords: gene level; methylation; level methylation; gene ... See more keywords
MAEL promoter hypermethylation is associated with de-repression of LINE-1 in human hypospermatogenesis
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DOI: 10.1093/humrep/dex329
Abstract: STUDY QUESTION Does the hypermethylation of the maelstrom spermatogenic transposon silencer (MAEL) promoter and subsequent de-repression of transposable elements represent one of the causes of spermatogenic failure in infertile men? SUMMARY ANSWER Experimental hypermethylation of… read more here.
Keywords: methylation; mael; mael promoter; hypermethylation ... See more keywords
THU0232 DIFFERENTIAL METHYLATION OF IL8 AND TISSUE FACTOR PROMOTER IN ANTIPHOSPHOLIPID SYNDROME
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.5459
Abstract: Background: Antiphospholipid syndrome (APS) is an autoimmune thrombophillia characterized by recurrent thromboembolism and/or pregnancy morbidity in the presence of Antiphospholipid antibodies mainly anti-β2glycoprotein I (anti-β2GPI), which lead to monocyte and endothelial cell activation and subsequent… read more here.
Keywords: methylation; tissue factor; il8; promoter ... See more keywords
Analyses of methylomes of upland and lowland switchgrass (Panicum virgatum) ecotypes using MeDIP-seq and BS-seq
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DOI: 10.1186/s12864-017-4218-0
Abstract: BackgroundSwitchgrass is a crop with many desirable traits for bioenergy production. Plant genomes have high DNA methylation levels throughout genes and transposable elements and DNA methylation is known to play a role in silencing transposable… read more here.
Keywords: seq; methylation; switchgrass; medip seq ... See more keywords
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis
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DOI: 10.1186/s12935-021-02343-7
Abstract: Background The ESR 1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed cancer in women that is also present in men. Methylation at promoter A of… read more here.
Keywords: cancer; methylation; cpg island; methylation levels ... See more keywords