Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma
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DOI: 10.1007/s00394-019-01925-6
Abstract: Objective(s) Isothiocyanates (ITCs) are biologically active plant secondary metabolites capable of mediating various biological effects including modulation of the epigenome. Our aim was to characterize the effect of allyl isothiocyanate (AITC) on lysine acetylation and… read more here.
Keywords: melanoma; methylation marks; malignant melanoma; lysine acetylation ... See more keywords
Heritable DNA methylation marks associated with susceptibility to breast cancer
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DOI: 10.1038/s41467-018-03058-6
Abstract: Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable methylation marks associated with breast cancer susceptibility by studying 25 Australian multiple-case breast… read more here.
Keywords: methylation; methylation marks; breast cancer; cancer ... See more keywords
Intergenerational transfer of DNA methylation marks in the honey bee.
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DOI: 10.1073/pnas.2017094117
Abstract: The evolutionary significance of epigenetic inheritance is controversial. While epigenetic marks such as DNA methylation can affect gene function and change in response to environmental conditions, their role as carriers of heritable information is often… read more here.
Keywords: methylation; methylation marks; methylation reprogramming; dna methylation ... See more keywords
Abstract 3314: Heritable methylation marks associated with prostate and breast cancer risk
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DOI: 10.1158/1538-7445.am2018-3314
Abstract: While most epigenetic marks are reprogrammed during early embryogenesis, some studies have reported Mendelian-like inheritance of germline DNA methylation in particular in cancer susceptibility genes. For instance, individuals with MLH1 silenced throughout the soma fit… read more here.
Keywords: methylation; risk; methylation marks; heritable methylation ... See more keywords