Pan-cancer characterization of long non-coding RNA and DNA methylation mediated transcriptional dysregulation
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103399
Abstract: Background Disruption of DNA methylation (DNAm) is one of the key signatures of cancer, however, detailed mechanisms that alter the DNA methylome in cancer remain to be elucidated. Methods Here we present a novel integrative… read more here.
Keywords: dna; cancer; gene; dna methylation ... See more keywords
Geminiviruses employ host DNA glycosylases to subvert DNA methylation-mediated defense
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28262-3
Abstract: DNA methylation is an epigenetic mechanism that plays important roles in gene regulation and transposon silencing. Active DNA demethylation has evolved to counterbalance DNA methylation at many endogenous loci. Here, we report that active DNA… read more here.
Keywords: dna; subvert dna; dna methylation; mediated defense ... See more keywords
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
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DOI: 10.1038/s41586-018-0751-5
Abstract: Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA methylation, which is predominantly mediated by DNMT3A, a de novo DNA methyltransferase1,2. Unlike the genome of sperm and most somatic cells, the… read more here.
Keywords: methylation; oocyte methylome; dna; stella ... See more keywords
Methylation Mediated Silencing of miR-155 Suppresses the Development of Preeclampsia In Vitro and In Vivo by Targeting FOXO3
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/4250621
Abstract: Preeclampsia (PE) is a common pregnancy-related syndrome characterized by chronic immune activation. This study is aimed at exploring the role of miR-155 in the inflammatory pathogenesis of PE. Placental tissues and peripheral blood were collected… read more here.
Keywords: mir 155; mediated silencing; silencing mir; methylation mediated ... See more keywords
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer
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DOI: 10.1186/s13148-021-01211-5
Abstract: Background Deregulated methylation of tumor suppressor genes is a hallmark event in colorectal cancer (CRC) carcinogenesis. UNC5 receptors, down-regulated in various human malignancies due to epigenetic alterations, have been proposed as putative tumor suppressor genes.… read more here.
Keywords: unc5c unc5d; methylation; unc5 receptors; methylation mediated ... See more keywords
Methylation-mediated LINC00261 suppresses pancreatic cancer progression by epigenetically inhibiting c-Myc transcription
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DOI: 10.7150/thno.44278
Abstract: Background: Due to the limitations of strategies for its early diagnosis and treatment, pancreatic cancer (PC) remains a substantial human health threat. We previously discovered a methylation-mediated lncRNA, LINC00261, which is downregulated in PC tissues.… read more here.
Keywords: myc transcription; methylation; mediated linc00261; pancreatic cancer ... See more keywords