Functional correlation of genome‐wide DNA methylation profiles in genetic neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24446
Abstract: An expanding range of genetic syndromes are characterized by genome‐wide disruptions in DNA methylation profiles referred to as episignatures. Episignatures are distinct, highly sensitive, and specific biomarkers that have recently been applied in clinical diagnosis… read more here.
Keywords: methylation; methylation profiles; dna methylation; genome wide ... See more keywords
Determining subpopulation methylation profiles from bisulfite sequencing data of heterogeneous samples using DXM
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab516
Abstract: Abstract Epigenetic changes, such as aberrant DNA methylation, contribute to cancer clonal expansion and disease progression. However, identifying subpopulation-level changes in a heterogeneous sample remains challenging. Thus, we have developed a computational approach, DXM, to… read more here.
Keywords: methylation; sequencing data; bisulfite sequencing; methylation profiles ... See more keywords
BIOM-62 SENSITIVE DETECTION AND DISCRIMINATION OF INTRACRANIAL TUMORS BY BLOOD
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.059
Abstract: The diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Non-invasive diagnostic approaches, particularly for patients with brain tumours, provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. We… read more here.
Keywords: dna methylation; brain; intracranial tumors; methylation profiles ... See more keywords
Docetaxel Targets Aggressive Methylation Profiles and Serves as a Radiosensitizer in High-Risk Meningiomas.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac206
Abstract: BACKGROUND Meningioma is the most common primary intracranial tumor in adults. A subset of these tumors recur and invade the brain, even after surgery and radiation, resulting in significant disability. There is currently no standard-of-care… read more here.
Keywords: methylation; methylation profiles; high risk; meningiomas ... See more keywords
Identification and Validation of a Prognostic Signature Based on Methylation Profiles and Methylation-Driven Gene DAB2 as a Prognostic Biomarker in Differentiated Thyroid Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1686316
Abstract: Recurrence is the major death cause of differentiated thyroid carcinoma (DTC), and a better understanding of recurrence risk at early stage may lead to make the optimal medical decision to improve patients' prognosis. The 2015… read more here.
Keywords: methylation; based methylation; methylation profiles; risk ... See more keywords
DNA methylation profiles of elderly individuals subjected to indentured childhood labor and trauma
Sign Up to like & getrecommendations! Published in 2017 at "BMC Medical Genetics"
DOI: 10.1186/s12881-017-0370-2
Abstract: BackgroundChildhood trauma is associated with increased vulnerability to mental and somatic disorders later in life. Epigenetic modifications such as DNA methylation are one potential mechanism through which such long-lasting impairments/consequences can be explained. The aim… read more here.
Keywords: methylation; childhood; elderly individuals; methylation profiles ... See more keywords
Circulating tumor cell methylation profiles reveal the classification and evolution of non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Translational lung cancer research"
DOI: 10.21037/tlcr-22-50
Abstract: Background The ability of circulating tumor cells (CTCs) to identify lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) could improve pathological diagnosis and the selection of treatments for non-small cell lung cancer (NSCLC). Previous… read more here.
Keywords: tumor; lung; cancer; methylation ... See more keywords
Analysis of the Epigenetic Signature of Cell Reprogramming by Computational DNA Methylation Profiles
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DOI: 10.2174/1574893614666190919103752
Abstract: DNA methylation plays an important role in the reprogramming process. Understanding the underlying molecular mechanism of reprogramming is crucial for answering fundamental questions regarding the transition of cell identity. In this study, based on the… read more here.
Keywords: methylation; cell reprogramming; dna; methylation profiles ... See more keywords
Shotgun proteomic investigation of methyltransferase and methylation profiles in lipopolysaccharide stimulated RAW264.7 murine macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical research"
DOI: 10.2220/biomedres.43.73
Abstract: Arginine methylation is a common post-translational modification which functions as an epigenetic regulator of transcription and plays a key role in various cell signaling pathways. The methylation of arginine residues is catalyzed by protein arginine… read more here.
Keywords: methylation; shotgun proteomic; methylation profiles; arginine methylation ... See more keywords
Analysis of DNA Methylation Profiles in Mandibular Condyle of Chicks With Crossed Beaks Using Whole-Genome Bisulfite Sequencing
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.680115
Abstract: Crossed beaks have been observed in at least 12 chicken strains around the world, which severely impairs their growth and welfare. To explore the intrinsic factor causing crossed beaks, this study measured the length of… read more here.
Keywords: methylation; mandibular condyle; methylation profiles; crossed beaks ... See more keywords
Sex differences in methylation profiles are apparent in medulloblastoma, particularly among SHH tumors
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1113121
Abstract: Background Medulloblastoma, the most common malignant pediatric brain tumor, displays marked sex differences in prevalence of the four main molecular subgroups: SHH, WNT, Group 3 and Group 4. Males are more frequently diagnosed with SHH,… read more here.
Keywords: methylation profiles; differences methylation; group; sex ... See more keywords