MGMT promoter methylation status as a prognostic factor for the outcome of gamma knife radiosurgery for recurrent glioblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2478-9
Abstract: We conducted this study to determine whether the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter was a prognostic marker for positive outcomes of gamma knife radiosurgery (GKS) for recurrent glioblastoma (GBM). We retrospectively examined… read more here.
Keywords: methylation; mgmt promoter; recurrent; methylation status ... See more keywords
Temporal stability of MGMT promoter methylation in glioblastoma patients undergoing STUPP protocol
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DOI: 10.1007/s11060-017-2722-3
Abstract: Epigenetic silencing of O-6-methylguanine-DNA methyltransferase (MGMT) promoter via methylation in a glioblastoma (GBM), has been correlated with a more favourable response to alkylating chemotherapeutic agents such as temozolomide. The use of global methylation surrogates such… read more here.
Keywords: status; methylation; mgmt promoter; methylation status ... See more keywords
hTERT promoter methylation status in peripheral blood leukocytes as a molecular marker of head and neck cancer progression
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Genetics"
DOI: 10.1007/s13353-018-0458-1
Abstract: Cancer cells, including head and neck cancer cell carcinoma (HNSCC), are characterized by an increased telomerase activity. This enzymatic complex is active in approximately 80–90% of all malignancies, and is regulated by various factors, including… read more here.
Keywords: methylation; blood leukocytes; methylation status; promoter ... See more keywords
Comprehensive analysis of epigenetically regulated genes in anergic T cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2016.10.006
Abstract: T cell anergy is one of the important mechanisms for immune tolerance. The results of many studies investigating the mechanism for T cell anergy induction have revealed that the expression of several genes was up-regulated… read more here.
Keywords: comprehensive analysis; methylation status; anergic cells; induction ... See more keywords
Neuropeptide receptor genes GHSR and NMUR1 are candidate epigenetic biomarkers and predictors for surgically treated patients with oropharyngeal cancer
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DOI: 10.1038/s41598-020-57920-z
Abstract: Pathological staging and histological grading systems are useful, but imperfect, predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Aberrant promoter methylation is the main type of epigenetic modification that plays a role… read more here.
Keywords: methylation; neuropeptide receptor; methylation status; promoter methylation ... See more keywords
Analysis at the single-cell level indicates an important role of heterogeneous global DNA methylation status on the progression of lung adenocarcinoma
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DOI: 10.1038/s41598-021-02786-y
Abstract: Aberrant DNA modifications affect the tumorigenesis and progression of lung cancer. However, the global methylation status of tumor cells and the heterogeneous methylation status of cells within the same tumor need further study. We used… read more here.
Keywords: dna; lung; methylation; methylation status ... See more keywords
Whole-genome DNA methylation status associated with clinical PTSD measures of OIF/OEF veterans
Sign Up to like & getrecommendations! Published in 2017 at "Translational Psychiatry"
DOI: 10.1038/tp.2017.129
Abstract: Emerging knowledge suggests that post-traumatic stress disorder (PTSD) pathophysiology is linked to the patients’ epigenetic changes, but comprehensive studies examining genome-wide methylation have not been performed. In this study, we examined genome-wide DNA methylation in… read more here.
Keywords: methylation; whole genome; methylation status; dna methylation ... See more keywords
New Insights into the Methylation Status of Virulent Diuraphis noxia (Hemiptera: Aphididae) Biotypes
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DOI: 10.1093/jee/toy039
Abstract: Abstract Epigenetic modifications provide a means for aphid biotype development that a lack of genetic variation, owing to an anholocyclic reproduction lifecycle, fails to do. Here we present data on the DNA methylation status in… read more here.
Keywords: aphididae biotypes; hemiptera aphididae; methylation; methylation status ... See more keywords
A Comparison of Three Different Deep Learning-Based Models to Predict the MGMT Promoter Methylation Status in Glioblastoma Using Brain MRI
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DOI: 10.1093/neuonc/noac209.673
Abstract: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The standard treatment for GBM consists of surgical resection followed by concurrent chemoradiotherapy and adjuvant temozolomide. O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is… read more here.
Keywords: promoter methylation; brain; mgmt promoter; methylation status ... See more keywords
Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multipool CEST MRI at 7.0 T
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DOI: 10.1093/neuonc/noy073
Abstract: Background Early identification of prognostic superior characteristics in glioma patients such as isocitrate dehydrogenase (IDH) mutation and O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is of great clinical importance. The study purpose was to investigate the non-invasive… read more here.
Keywords: status; idh mutation; methylation status; mri ... See more keywords
Methylation status of the stimulator of interferon genes promoter in patients with chronic hepatitis B
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DOI: 10.1097/md.0000000000013904
Abstract: Abstract The stimulator of interferon genes (STING) plays a crucial role in the recognition of a viral infection and subsequent stimulation of an immune response. However, it is unclear whether methylation of the STING promoter… read more here.
Keywords: methylation; response; methylation status; promoter ... See more keywords