Articles with "methylcyclopropyl" as a keyword



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Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.

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Published in 2019 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.8b01733

Abstract: Pim kinases are a family of constitutively active serine/threonine kinases that are partially redundant and regulate multiple pathways important for cell growth and survival. In human disease, high expression of the three Pim isoforms has… read more here.

Keywords: methylcyclopropyl; inhibitor; pim kinase; pim ... See more keywords