B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner
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DOI: 10.1021/acsomega.1c04659
Abstract: Colchicine, the main active alkaloid from Colchicum autumnale L., is a potent tubulin binder and represents an interesting lead structure for the development of potential anticancer chemotherapeutics. We report on the synthesis and investigation of… read more here.
Keywords: cancer; caspase independent; apoptosis; methylene colchicinoid ... See more keywords