CuI-catalyzed thioarylation of active methylene compounds with in situ generated benzenethiols: Preparation of α-thioaryl-β-dicarbonyls and 4-thioaryl-5-pyrazolones
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.07.049
Abstract: Abstract In this paper, a one-step copper-catalyzed procedure for oxidative coupling of active methylene compounds including cyclic β-diketones, cyclic β-ketoesters and 5-pyrazolone with benzenethiols is described. Benzenethiols are in situ generated in the reaction mixture… read more here.
Keywords: cui catalyzed; situ generated; thioaryl; active methylene ... See more keywords
Deep eutectic solvent: An efficient and green catalyst for the three-component condensation of indoles, aromatic aldehydes, and activated methylene compounds
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151481
Abstract: Abstract The deep eutectic solvent-catalyzed multicomponent reaction of aldehydes, indoles, and activated methylene compounds under sonication has been developed. The method proceeded well for a wide scope of substrates under mild condition to afford 3-substituted… read more here.
Keywords: catalyst; activated methylene; deep eutectic; eutectic solvent ... See more keywords
Unprecedented C–C Bond Formation via Ipso Nucleophilic Substitution of 2,4-Dinitrobenzene Sulfonic Acid with Active Methylene Compounds
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c06865
Abstract: The sulfonic acid functionalization of sufficiently electron-deficient benzene sulfonic acids undergoes ipso nucleophilic substitution with various active methylene compounds, leading to new C–C bond formation. Good to excellent yields are obtained under mild conditions without… read more here.
Keywords: sulfonic acid; active methylene; bond formation; methylene compounds ... See more keywords
Organoelectrocatalysis Enables Direct Cyclopropanation of Methylene Compounds.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12762
Abstract: Cyclopropane is a prevalent structural unit in natural products and bioactive compounds. While the transition metal-catalyzed alkene cyclopropanation of functionalized compounds such as α-diazocarbonyl derivatives has been well established and provides straightforward access to cyclopropanes,… read more here.
Keywords: enables direct; direct cyclopropanation; methylene compounds; cyclopropanation ... See more keywords
1,5-Phosphonium betaines from N-triflylpropiolamides, triphenylphosphane, and active methylene compounds
Sign Up to like & getrecommendations! Published in 2019 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.15.253
Abstract: N-Phenyl-N-(trifluoromethylsulfonyl)propiolamides react with triphenylphosphane in the presence of various active methylene compounds CH2XY in a 1:1:1 molar ratio to furnish 1-phosphonium-5-oxabetaines, Ph3P+–C(R)=CH–C(O–)=CXY. These betaines are formed preferentially, but not exclusively, as E-diastereoisomers with respect to… read more here.
Keywords: betaines triflylpropiolamides; triflylpropiolamides triphenylphosphane; phosphonium betaines; active methylene ... See more keywords