Biochemical analysis of patients with mutations in MTHFD1 and a diagnosis of methylenetetrahydrofolate dehydrogenase 1 deficiency.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2020.04.008
Abstract: MTHFD1 is a trifunctional protein containing 10-formyltetrahydrofolate synthetase, 5,10-methenyltetrahydrofolate cyclohydrolase and 5,10-methylenetetrahydrofolate dehydrogenase activities. It is encoded by MTHFD1 and functions in the cytoplasmic folate cycle where it is involved in de novo purine synthesis,… read more here.
Keywords: biochemical analysis; dehydrogenase; expression; methylenetetrahydrofolate dehydrogenase ... See more keywords
Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?
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DOI: 10.1097/cm9.0000000000002062
Abstract: Abstract Background: Excessive exposure to fluoride can reduce intelligence. Methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 (MTHFD1) polymorphisms have important roles in neurodevelopment. However, the association of MTHFD1 polymorphisms with children's intelligence changes in endemic… read more here.
Keywords: fluoride; intelligence; dehydrogenase cyclohydrolase; methylenetetrahydrofolate dehydrogenase ... See more keywords
Expression and Prognostic Value Identification of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Brain Low-Grade Glioma
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DOI: 10.2147/ijgm.s323858
Abstract: Objective This study aimed to reveal the potential function of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) and emphasized its importance in brain low-grade glioma (LGG). Methods We firstly explored the differential expression of MTHFD2 mRNA in LGG… read more here.
Keywords: expression; dehydrogenase mthfd2; methylenetetrahydrofolate dehydrogenase; mthfd2 ... See more keywords