Methylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patients
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23994
Abstract: Dyslipidemia in diabetes is common and characterized by hypertriglyceridemia with decreased levels of high‐density lipoprotein. The objective of this study was to assess the prevalence of MTHFR C677T polymorphism in Palestinian T2DM patients and to… read more here.
Keywords: reductase c677t; methylenetetrahydrofolate reductase; polymorphism; association ... See more keywords
Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase
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DOI: 10.1002/pro.4654
Abstract: Methylenetetrahydrofolate reductase (MTHFR) is a key metabolic enzyme in colonization and virulence of Neisseria meningitidis, a causative agent of meningococcal diseases. Here, the biochemical and structural properties of MTHFR from a virulent strain of N.… read more here.
Keywords: ch2 h4folate; biochemical structural; methylenetetrahydrofolate reductase;
Sex-specific effects of methylenetetrahydrofolate reductase polymorphisms on schizophrenia with methylation changes.
Sign Up to like & getrecommendations! Published in 2019 at "Comprehensive psychiatry"
DOI: 10.1016/j.comppsych.2019.152121
Abstract: BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) is the critical enzyme in biotransformation. The polymorphism of MTHFR is a risk factor for schizophrenia. However, whether the MTHFR polymorphism is associated with schizophrenia disease phenotypes and what is the… read more here.
Keywords: mthfr polymorphism; methylation; schizophrenia; methylenetetrahydrofolate reductase ... See more keywords
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
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DOI: 10.1038/s41467-018-04735-2
Abstract: The folate and methionine cycles are crucial for biosynthesis of lipids, nucleotides and proteins, and production of the methyl donor S-adenosylmethionine (SAM). 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a key regulatory connection between these cycles, generating 5-methyltetrahydrofolate… read more here.
Keywords: methylenetetrahydrofolate reductase; inhibition; mthfr; sam ... See more keywords
Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male mice
Sign Up to like & getrecommendations! Published in 2020 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2020.1769412
Abstract: ABSTRACT Objective: Elevated homocysteine concentrations are a risk factor for stroke. A common genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR 677 C→T) results in elevated levels of homocysteine. MTHFR plays a critical role in the synthesis… read more here.
Keywords: ischemic stroke; mice; damage; cellular response ... See more keywords
Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation
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DOI: 10.1080/15384101.2017.1363942
Abstract: ABSTRACT Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the folate cycle and its genetic variations have been associated with various human diseases. Previously we identified that MTHFR is phosphorylated by cyclin-dependent kinase 1 (CDK1)… read more here.
Keywords: plk1; methylenetetrahydrofolate reductase; kinase; reductase mthfr ... See more keywords
The methylenetetrahydrofolate reductase 1298 A>C polymorphism is associated with an increased risk of inflammatory bowel disease: evidence from a meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2021.1982384
Abstract: ABSTRACT Objective The association between genetic variants in methylenetetrahydrofolate reductase (MTHFR) and risk for inflammatory bowel disease (IBD) has been widely studied. However, the results are equivocal. In this meta-analysis, we aimed to determine the… read more here.
Keywords: meta analysis; 1298 polymorphism; risk; methylenetetrahydrofolate reductase ... See more keywords
T677T Methylenetetrahydrofolate Reductase Single Nucleotide Polymorphisms Increased Prevalence in a Subgroup of Infertile Patients with Endometriosis
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DOI: 10.1089/jwh.2022.0019
Abstract: Background: Approximately 10% (190 million) of women worldwide are affected by endometriosis, ectopic deposits of endometrial tissue that create a major source of pain that affects lifestyle and reproductive function. The pathogenesis of endometriosis is… read more here.
Keywords: methylenetetrahydrofolate reductase; endometriosis; patients endometriosis; single nucleotide ... See more keywords
Variable neurological phenotypes of homocystinuria caused by biallelic methylenetetrahydrofolate reductase variants
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DOI: 10.1097/mcd.0000000000000407
Abstract: Inherited methylenetetrahydrofolate reductase (MTHFR) deficiency is associated with a wide spectrum of disorders including homocystinuria. This study aims to describe the neurological phenotypes and molecular profiles of patients with homocystinuria caused by biallelic variants in… read more here.
Keywords: homocystinuria caused; neurological phenotypes; variable neurological; methylenetetrahydrofolate reductase ... See more keywords
Systematic review and meta‐analysis of the associations between maternal methylenetetrahydrofolate reductase polymorphisms and preterm delivery
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DOI: 10.1111/jog.13566
Abstract: To date, reported associations between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and preterm delivery are conflicting. The present meta‐analysis summarized the existing evidence and evaluated these associations. read more here.
Keywords: preterm delivery; polymorphisms preterm; methylenetetrahydrofolate reductase; meta analysis ... See more keywords
Pyoderma gangrenosum-like lesion secondary to methylenetetrahydrofolate reductase mutation: an unusual presentation of a rare disease
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DOI: 10.1136/bcr-2018-228403
Abstract: Pyoderma gangrenosum (PG)-like ulcerations are a rare clinical manifestation of methylenetetrahydrofolate reductase (MTHFR) mutation. We describe a patient considered to have PG who was treated with long-term high doses of systemic corticosteroids and multiple immunosuppressive… read more here.
Keywords: methylenetetrahydrofolate reductase; pyoderma gangrenosum; gangrenosum like; mutation ... See more keywords