Investigation of the methylglyoxal scavenging kinetics of different food matrices under simulated intestinal conditions
Sign Up to like & getrecommendations! Published in 2020 at "European Food Research and Technology"
DOI: 10.1007/s00217-020-03589-7
Abstract: This study aimed to evaluate the potential roles of different foods to scavenge exogenous dicarbonyl compounds under simulated gastrointestinal conditions. Four food groups having different arginine, creatine, thiol, and flavonoid contents were subjected to simulated… read more here.
Keywords: methylglyoxal scavenging; methylglyoxal; reaction; intestinal conditions ... See more keywords
Methylglyoxal at metronomic doses sensitizes breast cancer cells to doxorubicin and cisplatin causing synergistic induction of programmed cell death and inhibition of stemness
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.08.041
Abstract: Graphical abstract Figure. No Caption available. Abstract Potent anticancer activity coupled with absence of toxicity at therapeutic dose established the glycolytic metabolite, methylglyoxal, as a promising candidate against malignant neoplasia. In this preclinical study we… read more here.
Keywords: cancer; methylglyoxal; doxorubicin cisplatin; breast cancer ... See more keywords
Dysfunction of SERCA pumps as novel mechanism of methylglyoxal cytotoxicity.
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2018.06.003
Abstract: A novel pathway of methylglyoxal (MGX)-induced apoptosis via sarcoplasmic reticulum Ca2+-ATPase (SERCA) is presented. Interaction of SERCA1 with MGX was investigated by molecular docking and experimentally in a cell-free system. MGX concentration- and time-dependently decreased… read more here.
Keywords: mgx; methylglyoxal; decrease; dysfunction serca ... See more keywords
Methylglyoxal augments uridine diphosphate-induced contraction via activation of p38 mitogen-activated protein kinase in rat carotid artery.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174155
Abstract: The methylglyoxal elicits diverse adverse effects on the body. Uridine diphosphate, an extracellular nucleotide, plays an important role as a signaling molecule controlling vascular tone. This study aimed to evaluate the relationship between methylglyoxal and… read more here.
Keywords: uridine diphosphate; induced contraction; methylglyoxal; diphosphate ... See more keywords
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101114
Abstract: Objective The lack of effective treatments against diabetic sensorimotor polyneuropathy demands the search for new strategies to combat or prevent the condition. Because reduced magnesium and increased methylglyoxal levels have been implicated in the development… read more here.
Keywords: magnesium; methylglyoxal; diabetic sensorimotor; sensorimotor polyneuropathy ... See more keywords
Proteomic identification of aerobic glycolysis as a potential metabolic target for methylglyoxal in adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Nutrition research"
DOI: 10.1016/j.nutres.2020.06.009
Abstract: Obesity is often accompanied by metabolic changes in adipocytes that are closely associated with metabolic disease. Although high sugar consumption contributes to obesity, it may also directly affect adipocytes by increasing the rate of glycolysis… read more here.
Keywords: glycolysis; metabolic changes; aerobic glycolysis; identification aerobic ... See more keywords
In vitro evaluation of anti-methylglyoxal/glyoxal activity of three phytosterols using glycated bovine serum albumin models
Sign Up to like & getrecommendations! Published in 2020 at "Steroids"
DOI: 10.1016/j.steroids.2020.108678
Abstract: Reactive intermediate dicarbonyls, such as methylglyoxal (MGO) and glyoxal (GO), have received extensive attention recently due to their high reactivity and capability to form advanced glycation end products (AGEs) in foods, which have been implicated… read more here.
Keywords: glyoxal; activity; methylglyoxal; serum albumin ... See more keywords
Dietary Methylglyoxal Exposure Induces Alzheimer's Disease by Promoting Amyloid β Accumulation and Disrupting Autophagy in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03411
Abstract: Methylglyoxal (MG) is a precursor of advanced glycation end products usually generated during cooking. The high level of MG in the brain is correlated to the pathogenesis of Alzheimer's disease (AD). However, it is not… read more here.
Keywords: alzheimer disease; accumulation; caenorhabditis elegans; methylglyoxal ... See more keywords
Methylglyoxal modification reduces the sensitivity of hen egg white lysozyme to stress-induced aggregation: Insight into the anti-amyloidogenic property of α-dicarbonyl compound
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1702589
Abstract: Abstract The reactive α-oxoaldehyde, methylglyoxal reacts with different proteins to form Advanced Glycation End Products (AGEs) through Maillard reaction. Its level increases significantly in diabetic condition. Here, we have investigated the effect of different concentrations… read more here.
Keywords: methylglyoxal modification; hen egg; methylglyoxal; white lysozyme ... See more keywords
A ketogenic diet prevents methylglyoxal-evoked nociception by scavenging methylglyoxal.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002667
Abstract: ABSTRACT Methylglyoxal is a reactive dicarbonyl byproduct of glycolysis implicated in a growing number of neuropathic pain conditions, including chemotherapy-induced peripheral neuropathy, diabetic peripheral neuropathy, and radiculopathy with lumbar disc herniation. Recent studies show success… read more here.
Keywords: hydroxybutyrate methylglyoxal; evoked nociception; methylglyoxal; ketogenic diet ... See more keywords
Revealing a key inhibitory mechanism of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline via trapping of methylglyoxal.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of food science"
DOI: 10.1111/1750-3841.15305
Abstract: The inhibitory effects of vitamins (nicotinic acid, pyridoxamine [PM], and l-ascorbic acid) and phenolic acids (ferulic acid and p-coumaric acid) on the formation of 2-amino-3,8-dimethylimidazo [4,5-f] quinoxaline (MeIQx) were studied in a glycine/glucose/creatinine model system… read more here.
Keywords: mechanism; chemistry; formation; meiqx ... See more keywords