In vivo assignment of methylmalonic acid in breast tissue using 2D MRS and relationship with breast density, menopausal status and cancer risk
Sign Up to like & getrecommendations! Published in 2022 at "Nmr in Biomedicine"
DOI: 10.1002/nbm.4851
Abstract: Methylmalonic acid (MMA) is linked to progression and aggressiveness of tumours. A recent study showed that high levels of circulatory MMA directed genetic programs promoting cancer progression. read more here.
Keywords: breast; assignment methylmalonic; methylmalonic acid; vivo assignment ... See more keywords
The marker of cobalamin deficiency, plasma methylmalonic acid, may help identifying lysosomal iron trapping in patients. Its possible utility for heart failure
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102011
Abstract: Iron deficiency is known to aggravate the prognosis of patients with heart failure. Iron has functions in the mitochondrial respiratory chain. In patients with reduced mitochondrial respiration, the mitochondrial ratio between the level of nicotinamide… read more here.
Keywords: iron; methylmalonic acid; deficiency; heart failure ... See more keywords
Age-induced accumulation of methylmalonic acid promotes tumour progression
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2630-0
Abstract: The risk of cancer and associated mortality increases substantially in humans from the age of 65 years onwards 1 – 6 . Nonetheless, our understanding of the complex relationship between age and cancer is still in… read more here.
Keywords: age; methylmalonic acid; promotes tumour; tumour progression ... See more keywords
The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7043883
Abstract: Methylmalonic acid (MMA) can act as a diagnosis of hereditary methylmalonic acidemia and assess the status of vitamin B12. Moreover, as a new potential biomarker, it has been widely reported to be associated with the… read more here.
Keywords: regulation characterization; characterization mitochondrial; methylmalonic acid; oxidative stress ... See more keywords
Serum Methylmalonic Acid Mediates Aging-Related Cancer Aggressiveness.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-125
Abstract: Methylmalonic acid (MMA) from older donors' sera promoted cancer-cell invasiveness and metastasis. read more here.
Keywords: acid mediates; methylmalonic acid; cancer; serum methylmalonic ... See more keywords
Functional vitamin B12 deficiency in phenylketonuria patients and healthy controls: An evaluation with combined indicator of vitamin B12 status as a biochemical index
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical Biochemistry"
DOI: 10.1177/0004563220935140
Abstract: Background Vitamin B12 deficiency frequently appears in phenylketonuria patients having a diet poor in natural protein. The aims of this study were to evaluate vitamin B12 status in phenylketonuria patients by using combined indicator of… read more here.
Keywords: vitamin; b12 status; vitamin b12; methylmalonic acid ... See more keywords
Simultaneous determination of 3-hydroxypropionic acid, methylmalonic acid and methylcitric acid in dried blood spots: Second-tier LC-MS/MS assay for newborn screening of propionic acidemia, methylmalonic acidemias and combined remethylation disorders
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0184897
Abstract: Background and aims Increased propionylcarnitine levels in newborn screening are indicative for a group of potentially severe disorders including propionic acidemia (PA), methylmalonic acidemias and combined remethylation disorders (MMACBL). This alteration is relatively non-specific, resulting… read more here.
Keywords: methylmalonic acid; determination; hydroxypropionic acid; methylcitric acid ... See more keywords
Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.974938
Abstract: Aims Evidence regarding serum methylmalonic acid (MMA) levels and mortality in individuals with diabetes is limited. This study aimed to evaluate the correlation between MMA and all-cause and cause-specific deaths in patients with diabetes. Materials… read more here.
Keywords: mma; cause; mortality; risk ... See more keywords
Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165202
Abstract: Methylmalonic acid (MMA) is a very short dicarboxylic acid (methylpropanedioic acid; CH3CH(COOH)2; pKa1, 3.07; pKa2, 5.76) associated with vitamin B12 deficiency and many other patho-physiological conditions. In this work, we investigated several carboxylic groups-specific derivatization… read more here.
Keywords: human urine; coopfb; mma; acid ... See more keywords