The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Journal"
DOI: 10.1042/bcj20190500
Abstract: Most fatty acids (FAs) are straight chains and are synthesized by fatty acid synthase (FASN) using acetyl-CoA and malonyl-CoA units. Yet, FASN is known to be promiscuous as it may use methylmalonyl-CoA instead of malonyl-CoA… read more here.
Keywords: coa; branched fas; echdc1; methylmalonyl coa ... See more keywords
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aay0934
Abstract: Itaconate brings metalloenzyme to a halt Controlled radicals enable unusual enzymatic transformations, but radical generation and management require dedicated systems. Ruetz et al. investigated how the immunometabolite itaconate might undermine these intricate systems to inhibit… read more here.
Keywords: itaconate; itaconyl coa; coa; methylmalonyl coa ... See more keywords