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Published in 2017 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.6b00460
Abstract: Among opioids, morphinans are of major importance as the most effective analgesic drugs acting primarily via μ-opioid receptor (μ-OR) activation. Our long-standing efforts in the field of opioid analgesics from the class of morphinans led…
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Keywords:
methylmorphinan ones;
opioid receptor;
activity relationship;
structure activity ... See more keywords
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Published in 2021 at "Molecules"
DOI: 10.3390/molecules26185677
Abstract: Adequate pain management, particularly chronic pain, remains a major challenge associated with modern-day medicine. Current pharmacotherapy offers unsatisfactory long-term solutions due to serious side effects related to the chronic administration of analgesic drugs. Morphine and…
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Keywords:
methylmorphinan ones;
chemical pharmacological;
pharmacological developments;
recent chemical ... See more keywords