Methylnaltrexone bromide for the treatment of opioid-induced constipation
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DOI: 10.1080/14656566.2018.1491549
Abstract: ABSTRACT Introduction: The extensive and alarming use of opioids for pain management in patients with chronic pain receiving palliative care is associated with non-tolerable gastrointestinal (GI) adverse effects. Opioid-induced constipation (OIC) is the most common… read more here.
Keywords: methylnaltrexone bromide; induced constipation; treatment; opioid induced ... See more keywords
Oral methylnaltrexone does not negatively impact analgesia in patients with opioid-induced constipation and chronic noncancer pain
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DOI: 10.2147/jpr.s160488
Abstract: Purpose An oral formulation of methylnaltrexone has been developed for treating opioid-induced constipation (OIC). This manuscript examines the impact of oral methylnaltrexone, a peripherally acting ยต-opioid receptor antagonist, on opioid analgesia. Methods This Phase III,… read more here.
Keywords: induced constipation; oral methylnaltrexone; opioid induced; day ... See more keywords
Safety of oral methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain
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DOI: 10.2147/jpr.s170086
Abstract: Purpose Oral methylnaltrexone was shown to be effective in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain in a Phase III randomized controlled trial. This report provides a detailed safety analysis from that… read more here.
Keywords: noncancer pain; chronic noncancer; methylnaltrexone; oral methylnaltrexone ... See more keywords